2019
The role of home sleep testing for evaluation of patients with excessive daytime sleepiness: focus on obstructive sleep apnea and narcolepsy
Rosenberg R, Hirshkowitz M, Rapoport DM, Kryger M. The role of home sleep testing for evaluation of patients with excessive daytime sleepiness: focus on obstructive sleep apnea and narcolepsy. Sleep Medicine 2019, 56: 80-89. PMID: 30803831, DOI: 10.1016/j.sleep.2019.01.014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHome sleep apnea testingObstructive sleep apneaExcessive daytime sleepinessSleep disordersSleep apneaEvaluation of EDSLow cerebrospinal fluid (CSF) hypocretin (orexin) levelsCerebrospinal fluid hypocretin levelsEvaluation of patientsDifferential clinical characteristicsDiagnosis of narcolepsySleep apnea testingHome sleep testingClinical characteristicsExcessive daytimeHypocretin levelsSleep testingApnea testingConsensus guidelinesLaboratory polysomnographyNarcolepsy diagnosisDaytime sleepinessCommon complaintMedical conditionsSubstantial burden
2014
Sleep in Patients with Restrictive Lung Disease
Won CH, Kryger M. Sleep in Patients with Restrictive Lung Disease. Clinics In Chest Medicine 2014, 35: 505-512. PMID: 25156766, DOI: 10.1016/j.ccm.2014.06.006.ChaptersConceptsRestrictive lung diseaseLung diseaseObesity hypoventilation syndromeInterstitial lung diseasePathophysiology of sleepImpact of treatmentOverall prognosisVentilatory defectHypoventilation syndromeImpaired ventilationDaytime fatigueSleep disruptionRelated symptomsSleep disordersSleep qualityDiffusion impairmentNeuromuscular diseaseDiseasePatientsPathophysiologySleepHypoxemiaHypercarbiaPrognosisDysfunction
2008
The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease
Kryger M, Roth T, Wang-Weigand S, Zhang J. The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease. Sleep And Breathing 2008, 13: 79-84. PMID: 18584227, DOI: 10.1007/s11325-008-0196-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultComorbidityCross-Over StudiesDouble-Blind MethodFemaleHumansIndenesMaleOximetryPolysomnographyPulmonary Disease, Chronic ObstructiveReceptors, MelatoninSeverity of Illness IndexSleep Apnea SyndromesSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersSleep StagesYoung AdultConceptsSevere chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseEffects of ramelteonObstructive pulmonary diseasePulmonary diseaseMean SaO2Respiratory depressant effectsApnea-hypopnea indexPoor sleep qualityTotal sleep timeMelatonin receptor agonistResultsNo significant differencesSignificant differencesAbnormal breathing eventsRamelteon 8Primary endpointAdverse eventsPersistent sleepCrossover studyDepressant effectPolysomnographic monitoringReceptor agonistRespiratory effortInsomnia treatmentSleep quality
2005
Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease
Singh H, Pollock R, Uhanova J, Kryger M, Hawkins K, Minuk GY. Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease. Digestive Diseases And Sciences 2005, 50: 2338-2343. PMID: 16416185, DOI: 10.1007/s10620-005-3058-y.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseSymptoms of OSANonalcoholic fatty liverObstructive sleep apneaFatty liver diseaseNAFLD patientsNASH patientsNonalcoholic steatohepatitisRisk factorsLiver diseaseSleep apneaInsulin resistancePrevalence of OSASleep apnea questionnaireIndependent risk factorPrevalence of diabetesBody mass indexPeripheral insulin resistanceLiver biopsyFatty liverMass indexTriglyceride levelsQuestionnaire criteriaPrevalence ratesPatients
2002
Gender and Obstructive Sleep Apnea Syndrome, Part 1: Clinical Features
Kapsimalis F, Kryger MH. Gender and Obstructive Sleep Apnea Syndrome, Part 1: Clinical Features. Sleep 2002, 25: 409-416. PMID: 12071542, DOI: 10.1093/sleep/25.4.409.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apnea syndromeSleep apnea syndromeApnea syndromeGeneral populationPrevalence of OSASOSAS casesPolysomnography findingsMale predominanceClinical featuresClinical presentationFemale patientsClinic populationEpidemiologic studiesPathophysiologic studiesSyndromeFemalesMalesPopulationLatest studiesPatientsPrevalenceDiseaseStudyOnly malesWomenWhat Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis?
Smith R, Ronald J, Delaive K, Walld R, Manfreda J, Kryger MH. What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis? CHEST Journal 2002, 121: 164-172. PMID: 11796446, DOI: 10.1378/chest.121.1.164.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeBody mass indexChronic obstructive airways diseaseObstructive airways diseaseHealth care utilizationSleep apnea patientsControl subjectsApnea patientsAirway diseaseOSAS patientsCardiovascular diseaseObstructive sleep apnea patientsHealth care utilization measuresApnea-hypopnea indexCongestive heart failureEffect of obesityIschemic heart diseaseSleep apnea syndromeDegree of hypoxemiaSignificant independent predictorsLogistic regression analysisCertain cardiovascular disordersHealth care resourcesRegression analysisApnea syndrome
1998
Obstructive sleep apnea patients use more health care resources ten years prior to diagnosis.
Ronald J, Delaive K, Roos L, Manfreda J, Kryger M. Obstructive sleep apnea patients use more health care resources ten years prior to diagnosis. Sleep Research Online : SRO 1998, 1: 71-4. PMID: 11382859.Peer-Reviewed Original ResearchConceptsOSA patientsObstructive sleep apnea syndrome (OSAS) patientsHealth care utilization recordsPatient health care utilizationSleep apnea syndrome patientsObstructive sleep apnea patientsHealth care utilizationSleep apnea patientsOSAS patientsMore hospitalizationsCare utilizationApnea patientsOSAS diagnosisSyndrome patientsGeneral populationPatientsUtilization recordsTen yearsDiagnosisTen-year periodYearsTen-year intervalsComorbiditiesHospitalizationHeavy users
1995
Successful Treatment of Comorbid Panic Disorder and Sleep Apnea With Continuous Positive Airway Pressure
Enns M, Stein M, Kryger M. Successful Treatment of Comorbid Panic Disorder and Sleep Apnea With Continuous Positive Airway Pressure. Journal Of The Academy Of Consultation-Liaison Psychiatry 1995, 36: 585-586. PMID: 7501792, DOI: 10.1016/s0033-3182(95)71620-6.Peer-Reviewed Original Research
1993
Review: Sleep in Heart Failure
Yamashiro Y, Kryger M. Review: Sleep in Heart Failure. Sleep 1993, 16: 513-523. PMID: 8235235, DOI: 10.1093/sleep/16.6.513.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements