2022
Comparison of Ring Pulse Oximetry Using Reflective Photoplethysmography and PSG in the Detection of OSA in Chinese Adults: A Pilot Study
Zhao R, Xue J, Zhang X, Peng M, Li J, Zhou B, Zhao L, Penzel T, Kryger M, Dong XS, Gao Z, Han F. Comparison of Ring Pulse Oximetry Using Reflective Photoplethysmography and PSG in the Detection of OSA in Chinese Adults: A Pilot Study. Nature And Science Of Sleep 2022, 14: 1427-1436. PMID: 36003191, PMCID: PMC9394522, DOI: 10.2147/nss.s367400.Peer-Reviewed Original ResearchEvents/hOxygen desaturation indexIntraclass correlation coefficientPulse oximetryChinese adultsThreshold of AHIObstructive sleep apneaDetection of OSAPositive likelihood ratioChinese Han subjectsOxygen desaturationDesaturation indexSleep apneaMean ageSimultaneous polysomnographyOxygen saturationPSG-AHIPolysomnographySleep laboratorySleep timePilot studyHan subjectsAHIOximetryCumulative percentage
2016
Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea.
Sun H, Palcza J, Card D, Gipson A, Rosenberg R, Kryger M, Lines C, Wagner JA, Troyer MD. Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea. Journal Of Clinical Sleep Medicine 2016, 12: 9-17. PMID: 26194728, PMCID: PMC4702197, DOI: 10.5664/jcsm.5382.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaOrexin receptor antagonistMean AHIRespiratory effectsSleep apneaMultiple dosesReceptor antagonistIntra-individual variabilityModerate obstructive sleep apneaEffects of suvorexantLowest effective doseSleep laboratory studiesTotal sleep timeMean SpO2Single doseRespiratory functionOxygen saturationPulse oximetryPlaceboPatientsSleep timeAHIDay 4Mean increaseSuvorexant
2011
Positive Airway Pressure Initiation: A Randomized Controlled Trial to Assess the Impact of Therapy Mode and Titration Process on Efficacy, Adherence, and Outcomes
Kushida CA, Berry RB, Blau A, Crabtree T, Fietze I, Kryger MH, Kuna ST, Pegram GV, Penzel T. Positive Airway Pressure Initiation: A Randomized Controlled Trial to Assess the Impact of Therapy Mode and Titration Process on Efficacy, Adherence, and Outcomes. Sleep 2011, 34: 1083-1092. PMID: 21804670, PMCID: PMC3138163, DOI: 10.5665/sleep.1166.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureMinimum oxygen saturationAirway pressureFunctional outcomeOxygen saturationVeterans Affairs Medical CenterPositive pressure treatmentApnea-hypopnea indexObstructive sleep apneaSevere OSAMulticenter trialTreatment satisfactionControlled TrialsSleep apneaMajor efficacyStudy treatmentOutcome measuresMedical CenterSleep qualityTherapy modesMask comfortAdherenceEfficacyMonths
2007
Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea
Kryger M, Wang-Weigand S, Roth T. Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea. Sleep And Breathing 2007, 11: 159-164. PMID: 17294232, DOI: 10.1007/s11325-006-0096-4.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaNext-day residual effectsApnea-hypopnea indexSleep apneaPost-sleep questionnaireAdverse eventsSelective MT1/MT2 receptor agonistMT1/MT2 receptor agonistMT2 receptor agonistSafety of ramelteonUrinary tract infectionArterial oxygen saturationControl of breathingRespiratory inductance plethysmographyRamelteon groupPlacebo groupTract infectionsCrossover studyWashout periodDepressant effectSleep QuestionnaireHypopneic eventsRespiratory effortInsomnia treatmentOxygen saturation
1993
Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration
Biberdorf D, Steens R, Millar T, Kryger M. Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration. Sleep 1993, 16: 529-538. PMID: 8235237, DOI: 10.1093/sleep/16.6.529.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureTotal sleep timePercentage of TSTApnea/hypopnea indexOxygen saturationTotal wake timeEffects of temazepamHeart failureSleep architectureDouble-blind crossover trialSevere congestive heart failureOvernight oxygen saturationStage 1 sleepHours of sleepSleep stage proportionsCHF patientsHypopnea indexMale patientsDaytime somnolenceCrossover trialSignificant changesFrequent arousalsDaytime alertnessSleep timeEffects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease
Steens R, Pouliot Z, Millar T, Kryger M, George C. Effects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease. Sleep 1993, 16: 318-326. PMID: 8341892, DOI: 10.1093/sleep/16.4.318.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseModerate chronic obstructive pulmonary diseaseObstructive pulmonary diseaseEffects of zolpidemPulmonary diseaseDrug conditionsNocturnal arterial oxygen desaturationArterial oxygen desaturationApnea-hypopnea indexGroup of patientsArterial oxygen saturationNumber of awakeningsTotal sleep timeHours of sleepSignificant differencesSubjective sleep variablesNew hypnotic agentOxygen desaturationCrossover studyHypnotic agentsSleep problemsSleep qualityOxygen saturationSleep efficiencyActive drug
1991
Sleep quality in children with asthma treated with theophylline or cromolyn sodium
Avital A, Steljes D, Pasterkamp H, Kryger M, Sanchez I, Chernick V. Sleep quality in children with asthma treated with theophylline or cromolyn sodium. The Journal Of Pediatrics 1991, 119: 979-984. PMID: 1960623, DOI: 10.1016/s0022-3476(05)83062-8.Peer-Reviewed Original ResearchConceptsCromolyn sodiumTheophylline periodPlacebo-controlled trialArterial oxygen desaturationTheophylline blood levelsArterial oxygen saturationTotal sleep timeYears of ageOxygen desaturationPulmonary functionTheophylline treatmentBlood levelsChild's asthmaCentral originSleep latencyProtective effectSleep qualityOxygen saturationSleep efficiencySleep timeAsthmaMicrograms/SleepMovement timeTreatment
1989
Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea
Hanly P, George C, Millar T, Kryger M. Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea. CHEST Journal 1989, 95: 735-739. PMID: 2924602, DOI: 10.1378/chest.95.4.735.Peer-Reviewed Original ResearchConceptsVoluntary respiratory maneuversObstructive sleep apneaHR responseSleep apneaRespiratory maneuversMueller maneuverOxygen saturationVagal toneAbsence of hypoxemiaArterial oxygen saturationHeart rate responseObstructive apneaMouth pressureApneaHR changesMale subjectsRate responseBreath holdSimilar durationValsalvaSignificant differencesSignificant correlationOSASMajor determinantWakefulness
1988
Identification and Quantification of Apneas by Computer-based Analysis of Oxygen Saturation
George C, Millar T, Kryger M. Identification and Quantification of Apneas by Computer-based Analysis of Oxygen Saturation. American Journal Of Respiratory And Critical Care Medicine 1988, 137: 1238-1240. PMID: 3195821, DOI: 10.1164/ajrccm/137.5.1238.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexApnea-hypopnea eventsNight polysomnogramsObstructive sleep apneaSleep apneaOvernight studyOxygen saturationSaO2 changesPredictive valueFalse negative rateApneaApnea eventsPolysomnogramSaO2 dataMethod of detectionOverall numberDurationNegative rateTotal numberManual scoringSaO2Patients
1987
The Effect of Excessive Ethanol Ingestion on Sleep in Severe Chronic Obstructive Pulmonary Disease
Easton P, West P, Meatherall R, Brewster J, Lertzman M, Kryger M. The Effect of Excessive Ethanol Ingestion on Sleep in Severe Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 224-233. PMID: 3629084, DOI: 10.1093/sleep/10.3.224.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseSevere chronic obstructive pulmonary diseaseObstructive pulmonary diseaseSleep timePulmonary diseaseHeart rateEmphysematous chronic obstructive pulmonary diseaseExcessive ethanol ingestionSignificant O2 desaturationArterial oxygen saturationIngestion of alcoholDose of ethanolSleep stagesExcessive alcohol ingestionTotal sleep timeMean heart ratePremature ventricular contractionsCOPD altersAlcohol ingestionO2 desaturationEthanol ingestionOxygen saturationVentricular contractionsREM timeSerum ethanolSnoring in Normal Young Adults: Prevalence in Sleep Stages and Associated Changes in Oxygen Saturation, Heart Rate, and Breathing Pattern
Perez-Padilla J, West P, Kryger M. Snoring in Normal Young Adults: Prevalence in Sleep Stages and Associated Changes in Oxygen Saturation, Heart Rate, and Breathing Pattern. Sleep 1987, 10: 249-253. PMID: 3629087, DOI: 10.1093/sleep/10.3.249.Peer-Reviewed Original ResearchConceptsHeart rateContinuous snoringSleep stagesOxygen saturationPrevalence of snoringSignificant O2 desaturationMean heart rateNormal young adultsMean SaO2O2 desaturationDifferent pathogenesisDifferent sleep stagesNormal subjectsBreathing patternLight snorersBreathing frequencySnoringArrhythmiasYoung adultsPrevalenceStage 3Same sleep stageStage 2Associated ChangesSubjectsDynamic in Vivo Response Characteristics of Three Oximeters: Hewlett-Packard 47201A, Biox III, and Nellcor N-100
West P, George C, Kryger M. Dynamic in Vivo Response Characteristics of Three Oximeters: Hewlett-Packard 47201A, Biox III, and Nellcor N-100. Sleep 1987, 10: 263-271. PMID: 3629089, DOI: 10.1093/sleep/10.3.263.Peer-Reviewed Original ResearchConceptsOxygen saturation measurementsHeart rateSaO2 measurementsOxygen saturationSleep apnea syndrome patientsArterial oxygen saturationPulse oximeterHewlett-Packard 47201ASyndrome patientsLinear regression analysisSaturation measurementsNellcor NOximeter sensorBiox IIIOximeterPatientsRegression analysisResponse relationshipSleepPulse oximeter sensorSaO2Oxygenation and Breathing Pattern During Phasic and Tonic REM in Patients with Chronic Obstructive Pulmonary Disease
George C, West P, Kryger M. Oxygenation and Breathing Pattern During Phasic and Tonic REM in Patients with Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 234-243. PMID: 3629085, DOI: 10.1093/sleep/10.3.234.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseTonic REMPhasic REMBreathing patternOxygen desaturationPulmonary diseaseSevere chronic obstructive pulmonary diseaseBreathing pattern changesAwake SaO2Nadir SaO2Total REMRespiratory neuronsMore desaturationMotor neuronsOxygen saturationREM sleepSaO2SaO2 differenceTransient decreaseRespiratory amplitudeNight studiesSleepDesaturationPatients
1986
Breathing during Sleep in Normal Pregnant Women1–3
Brownell L, West P, Kryger M. Breathing during Sleep in Normal Pregnant Women1–3. American Journal Of Respiratory And Critical Care Medicine 1986, 133: 38-41. PMID: 3942378, DOI: 10.1164/arrd.1986.133.1.38.Peer-Reviewed Original ResearchConceptsLate pregnancyMinimal arterial oxygen saturationMaternal oxygen desaturationFrequency of apneaRespiratory sleep studiesAlveolar-arterial differenceArterial oxygen saturationFunctional residual capacityLevels of progesteroneSleep-related apneaTotal apneaOxygen desaturationMaternal oxygenationComplete polysomnographyWk gestationPregnant womenCardiac outputLast trimesterPhysiologic changesResidual volumeSupine positionSleep studiesOxygen saturationPregnancyApnea
1985
Breathing during Sleep in Patients with Interstitial Lung Disease1–3
Perez-Padilla R, West P, Lertzman M, Kryger M. Breathing during Sleep in Patients with Interstitial Lung Disease1–3. American Journal Of Respiratory And Critical Care Medicine 1985, 132: 224-9. PMID: 2411177, DOI: 10.1164/arrd.1985.132.2.224.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseTi/TtotControl subjectsSleep qualityREM sleepRapid shallow breathing patternSex-matched control subjectsIncidence of snoringShallow breathing patternIncidence of apneaPoor sleep qualityAwake SaO2Lung diseaseExpiratory timeInspiratory timeLung reflexesOxygen saturationGreater abnormalitiesNREM sleepSleep structureHypopnea periodsBreathing patternPatientsVolume indexSleep
1980
Sleep Breathing Abnormalities in Kyphoscoliosis1–3
Mezon B, West P, Israels J, Kryger M. Sleep Breathing Abnormalities in Kyphoscoliosis1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 617-21. PMID: 7436128, DOI: 10.1164/arrd.1980.122.4.617.Peer-Reviewed Original ResearchConceptsBreathing abnormalitiesGreater oxygen desaturationPulmonary function testsArterial oxygen saturationCor pulmonaleChronic hypoxemiaOxygen desaturationCentral apneaFunction testsClinical evidencePhysiologic disturbancesSevere kyphoscoliosisMovement sleepSevere derangementThoracic deformityArterial PCO2Oxygen saturationSevere episodesChemical driveAbnormalitiesSleepPatientsDerangementPulmonaleHypoxemia
1978
Impaired Oxygenation During Sleep in Excessive Polycythemia of High Altitude: Improvement with Respiratory Stimulation
Kryger M, Glas R, Jackson D, McCullough R, Scoggin C, Grover R, Weil J. Impaired Oxygenation During Sleep in Excessive Polycythemia of High Altitude: Improvement with Respiratory Stimulation. Sleep 1978, 1: 3-17. PMID: 756057, DOI: 10.1093/sleep/1.1.3.Peer-Reviewed Original ResearchConceptsMedroxyprogesterone acetatePolycythemic patientsSevere hypoxemiaExcessive polycythemiaDouble-blind crossover trialMean lowest SaO2REM stage sleepDegree of hypoxemiaHigh-altitude residentsAwake SaO2Nocturnal SaO2Sleep hypoxemiaStage sleepImpaired oxygenationCrossover trialMean SaO2Lowest SaO2Control subjectsHypoxemiaTherapeutic effectOxygen saturationExcessive hypoxemiaSaO2Breathing patternPatients