1991
Effect of Theophylline on Lung Function Tests, Sleep Quality, and Nighttime SaO2 in Children with Cystic Fibrosis
Avital A, Sanchez I, Holbrow J, Kryger M, Chernick V. Effect of Theophylline on Lung Function Tests, Sleep Quality, and Nighttime SaO2 in Children with Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 1991, 144: 1245-1249. PMID: 1741534, DOI: 10.1164/ajrccm/144.6.1245.Peer-Reviewed Original ResearchConceptsEffect of theophyllineCystic fibrosisMicrograms/Heart rateGroup 2Better baseline lung functionT blood levelsBaseline lung functionIncidence of apneaLung function testsSerum T levelsLower heart rateTotal wake timePulmonary functionLung functionSerum levelsFunction testsMean SaO2Blood levelsSleep qualitySleep efficiencyGroup 1Sleep laboratoryT levelsWake time
1987
Hypercapnia and Sleep O2 Desaturation in Chronic Obstructive Pulmonary Disease
Kryger M, Rogelio P, Conway W, Roth T, Anthonisen N, George C. Hypercapnia and Sleep O2 Desaturation in Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 216-223. PMID: 3629083, DOI: 10.1093/sleep/10.3.216.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseBlue bloatersPink puffersSleep hypoxemiaPulmonary diseaseO2 desaturationHypoxemic chronic obstructive pulmonary diseaseNocturnal Oxygen Therapy TrialBetter lung functionArterial blood gasesWide clinical spectrumHypercapnic patientsSame PaO2Sleep oxygenationSleep SaO2Airflow obstructionHypoxemic patientsPulmonary hypertensionCOPD populationHypercapnic groupMost patientsNormocapnic patientsLung functionBlood gases
1980
Chemical Control of Ventilation and Sleep Arterial Oxygen Desaturation in Patients with COPD1–3
Fleetham J, Mezon B, West P, Bradley C, Anthonisen N, Kryger M. Chemical Control of Ventilation and Sleep Arterial Oxygen Desaturation in Patients with COPD1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 583-9. PMID: 7436124, DOI: 10.1164/arrd.1980.122.4.583.Peer-Reviewed Original ResearchConceptsO2 saturationSleep desaturationVentilatory sensitivityRapid eye movement (REM) sleepNocturnal changesArterial oxygen desaturationLowest O2 saturationHypoxic ventilatory responseArterial O2 saturationEye movement sleepHypoxemic COPDNocturnal desaturationOxygen desaturationLung functionBlood gasesVentilatory responseMovement sleepVentilatory controlPatientsMaximal desaturationSleepDesaturationSleep stagesHypercapniaWakefulness