2014
Sleep in Patients with Restrictive Lung Disease
Won CH, Kryger M. Sleep in Patients with Restrictive Lung Disease. Clinics In Chest Medicine 2014, 35: 505-512. PMID: 25156766, DOI: 10.1016/j.ccm.2014.06.006.ChaptersConceptsRestrictive lung diseaseLung diseaseObesity hypoventilation syndromeInterstitial lung diseasePathophysiology of sleepImpact of treatmentOverall prognosisVentilatory defectHypoventilation syndromeImpaired ventilationDaytime fatigueSleep disruptionRelated symptomsSleep disordersSleep qualityDiffusion impairmentNeuromuscular diseaseDiseasePatientsPathophysiologySleepHypoxemiaHypercarbiaPrognosisDysfunction
2000
Diagnosis and management of sleep apnea syndrome
Kryger M. Diagnosis and management of sleep apnea syndrome. Clinical Cornerstone 2000, 2: 39-44. PMID: 10875045, DOI: 10.1016/s1098-3597(00)90039-5.Peer-Reviewed Original ResearchConceptsSleep apnea syndromeApnea syndromeContinuous positive airway pressureMain presenting symptomPositive airway pressureSleep breathing disordersConstellation of signsPresenting symptomAirway pressureMost patientsExcessive daytimeSleep apneaBreathing disordersAbnormal breathingComplete resolutionSleep disruptionBusy cliniciansSymptomsSyndromeSleepDiagnosisDisordersEpisodesHypoxemiaApnea
1985
Sleep in Restrictive Lung Disorders
Kryger M. Sleep in Restrictive Lung Disorders. Clinics In Chest Medicine 1985, 6: 675-677. PMID: 3853479, DOI: 10.1016/s0272-5231(21)00404-4.Peer-Reviewed Original Research
1982
Diagnosis of sleep breathing disorders in a general hospital. Experience and recommendations.
Kryger M, Mezon B, Acres J, West P, Brownell L. Diagnosis of sleep breathing disorders in a general hospital. Experience and recommendations. JAMA Internal Medicine 1982, 142: 956-9. PMID: 7082118, DOI: 10.1001/archinte.142.5.956.Peer-Reviewed Original ResearchDiagnosis of Sleep Breathing Disorders in a General Hospital: Experience and Recommendations
Kryger M, Mezon B, Acres J, West P, Brownell L. Diagnosis of Sleep Breathing Disorders in a General Hospital: Experience and Recommendations. JAMA Internal Medicine 1982, 142: 956-958. DOI: 10.1001/archinte.1982.00340180114021.Peer-Reviewed Original Research
1980
The Effect of Low Flow Oxygen Therapy on the Chemical Control of Ventilation in Patients with Hypoxemic COPD1–3
Fleetham J, Bradley C, Kryger M, Anthonisen N. The Effect of Low Flow Oxygen Therapy on the Chemical Control of Ventilation in Patients with Hypoxemic COPD1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 833-40. PMID: 6779682, DOI: 10.1164/arrd.1980.122.6.833.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseHypoxemic chronic obstructive pulmonary diseaseOxygen therapyHypoxic responseLow-flow oxygen therapyCentral ventilatory driveFlow oxygen therapyNocturnal oxygen therapyObstructive pulmonary diseaseArterial O2 saturationNocturnal oxygenPulmonary diseaseSuch patientsVentilatory driveMinute ventilationInspiratory flowO2 saturationPatientsTherapyContinuous oxygenMonthsHypoxiaInitial responseHypoxemiaVentilationSleep apnea in acromegaly
Mezon B, West P, Maclean J, Kryger M. Sleep apnea in acromegaly. The American Journal Of Medicine 1980, 69: 615-623. PMID: 7424949, DOI: 10.1016/0002-9343(80)90477-5.Peer-Reviewed Original ResearchConceptsUpper airway obstructionSleep apnea syndromeAirway obstructionApnea syndromeSomnolent patientsSevere hypoxemiaPharyngeal airwayUpper airwayNormal sleepLarge tonguePatientsAcromegalyObstructionAirwaySyndromeSleepPeriodic obstructionTongueHypoxemiaSomnolenceTracheostomyApneaEndoscopyLarynxPharynxSleep Breathing Abnormalities in Kyphoscoliosis1–3
Mezon B, West P, Israels J, Kryger M. Sleep Breathing Abnormalities in Kyphoscoliosis1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 617-21. PMID: 7436128, DOI: 10.1164/arrd.1980.122.4.617.Peer-Reviewed Original ResearchConceptsBreathing abnormalitiesGreater oxygen desaturationPulmonary function testsArterial oxygen saturationCor pulmonaleChronic hypoxemiaOxygen desaturationCentral apneaFunction testsClinical evidencePhysiologic disturbancesSevere kyphoscoliosisMovement sleepSevere derangementThoracic deformityArterial PCO2Oxygen saturationSevere episodesChemical driveAbnormalitiesSleepPatientsDerangementPulmonaleHypoxemia
1978
Excessive Polycythemia of High Altitude: Role of Ventilatory Drive and Lung Disease1–3
Kryger M, McCullough R, Doekel R, Collins D, Weil J, Grover R. Excessive Polycythemia of High Altitude: Role of Ventilatory Drive and Lung Disease1–3. American Journal Of Respiratory And Critical Care Medicine 1978, 118: 659-666. PMID: 707889, DOI: 10.1164/arrd.1978.118.4.659.Peer-Reviewed Original ResearchConceptsCause of hypoxemiaExcessive polycythemiaPolycythemic patientsTidal volumeNormal subjectsExcessive hypoxemiaChemical driveAbnormal breathing patternsAlveolar-arterial differenceSmall tidal volumesHigh-altitude residentsRespiratory QuestionnaireSpirometric featuresHypoxic depressionVentilatory driveLung diseaseControl subjectsVentilatory responseMinute ventilationNormal lungBreathing patternHypoxemiaPatientsPolycythemiaDead spaceImpaired Oxygenation During Sleep in Excessive Polycythemia of High Altitude: Improvement with Respiratory Stimulation
Kryger M, Glas R, Jackson D, McCullough R, Scoggin C, Grover R, Weil J. Impaired Oxygenation During Sleep in Excessive Polycythemia of High Altitude: Improvement with Respiratory Stimulation. Sleep 1978, 1: 3-17. PMID: 756057, DOI: 10.1093/sleep/1.1.3.Peer-Reviewed Original ResearchConceptsMedroxyprogesterone acetatePolycythemic patientsSevere hypoxemiaExcessive polycythemiaDouble-blind crossover trialMean lowest SaO2REM stage sleepDegree of hypoxemiaHigh-altitude residentsAwake SaO2Nocturnal SaO2Sleep hypoxemiaStage sleepImpaired oxygenationCrossover trialMean SaO2Lowest SaO2Control subjectsHypoxemiaTherapeutic effectOxygen saturationExcessive hypoxemiaSaO2Breathing patternPatients
1976
Clinical Semi-Starvation — Depression of Hypoxic Ventilatory Response
Doekel R, Zwillich C, Scoggin C, Kryger M, Weil J. Clinical Semi-Starvation — Depression of Hypoxic Ventilatory Response. New England Journal Of Medicine 1976, 295: 358-361. PMID: 819829, DOI: 10.1056/nejm197608122950703.Peer-Reviewed Original ResearchConceptsHypoxic ventilatory responseVentilatory responseHypercapnic ventilatory responseMetabolic rateRespiratory failureIntravenous fluidsDecreased metabolic rateCarbohydrate dietNormal subjectsCaloric restrictionDay 10HypercapniaSupplemental electrolytesResponse responseSubjectsResponseHypoxemiaDecreaseHypoxiaAlimentation