2008
Influence of Sex on Sleep Regulatory Mechanisms
Paul KN, Turek FW, Kryger MH. Influence of Sex on Sleep Regulatory Mechanisms. Journal Of Women's Health 2008, 17: 1201-1208. PMID: 18710368, DOI: 10.1089/jwh.2008.0841.Peer-Reviewed Original ResearchConceptsSleep regulatory mechanismsRodent studiesSleep-wake disordersReproductive hormonesExtended wakefulnessHomeostatic sleep regulatory mechanismsSleep consolidationSleep-wake amountsActivational influencesBiological sexRapid eye movement (REM) sleepSleep-wake architectureSleep amountSleep-wake cycleEffects of sexFemale reproductive hormonesSleepEye movement sleepSleep-wake statesInfluence of sexSleep disordersSleep statesPositive impactWakefulnessNeonatal exposure
2006
Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome
Vagiakis E, Kapsimalis F, Lagogianni I, Perraki H, Minaritzoglou A, Alexandropoulou K, Roussos C, Kryger M. Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome. Sleep Medicine 2006, 7: 424-430. PMID: 16740405, DOI: 10.1016/j.sleep.2005.12.014.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeApnea-hypopnea indexBody mass indexSleep apnea syndromeMale patientsApnea syndromeFemale patientsOnset latencyMean apnea-hypopnea indexSleep apnea hypopnea indexHigher apnea-hypopnea indexNon-rapid eye movement sleepSleep disorders centerREM onset latencyEye movement sleepAthens Medical SchoolPercent of menSleep efficiency indexTotal sleep timeGreek subjectsAspects of sleepSleep onset latencyNorth American clinicsEvangelismos HospitalNREM-AHI
2005
Cytokines and normal sleep
Kapsimalis F, Richardson G, Opp MR, Kryger M. Cytokines and normal sleep. Current Opinion In Pulmonary Medicine 2005, 11: 481-484. PMID: 16217172, DOI: 10.1097/01.mcp.0000183062.98665.6b.Peer-Reviewed Original ResearchConceptsNon-rapid eye movement sleepEye movement sleepNeurohormonal systemsMovement sleepSpontaneous non-rapid eye movement sleepMultiple biologic actionsHypothalamic preoptic areaReceptor-mediated effectsTumor necrosis factorNitric oxide synthesisEffects of cytokinesDirect receptor-mediated effectsImmune system responseMechanism of actionSleep-wake regulationSite of actionAdrenal axisBasal forebrainPreoptic areaNecrosis factorInterleukin-1Adrenal axesNormal sleepCytokinesOxide synthesisLong-term treatment of sleep breathing disorder in a patient with Huntington's disease
Banno K, Hobson DE, Kryger MH. Long-term treatment of sleep breathing disorder in a patient with Huntington's disease. Parkinsonism & Related Disorders 2005, 11: 261-264. PMID: 15878590, DOI: 10.1016/j.parkreldis.2005.01.005.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep breathing disordersApnea-hypopnea indexBreathing disordersHuntington's diseaseRapid eye movement (REM) sleepPositive airway pressureObstructive sleep apneaLong-term treatmentEye movement sleepQuality of lifeAutosomal dominant neurodegenerative disorderAirway pressureHD patientsSleep apneaRespiratory arousalsMovement sleepDominant neurodegenerative disorderDaytime alertnessSleep structureNeurodegenerative disordersDiseaseDisordersApneaPatients
1993
Nocturnal Cluster Headache Associated with Sleep Apnea. A Case Report
Buckle P, Kerr P, Kryger M. Nocturnal Cluster Headache Associated with Sleep Apnea. A Case Report. Sleep 1993, 16: 487-489. PMID: 8378690, DOI: 10.1093/sleep/16.5.487.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaCluster headacheRapid eye movement (REM) sleepChronic cluster headacheEye movement sleepNasal CPAPOxygen desaturationCase reportMovement sleepHeadache AssociatedBackup rateREM sleepTypical headacheHeadacheApneaSleep labFurther treatmentSleepDesaturationTreatmentBiPAPCPAPMedications
1990
Sleep in Postpolio Syndrome
Steljes D, Kryger M, Kirk B, Millar T. Sleep in Postpolio Syndrome. CHEST Journal 1990, 98: 133-140. PMID: 2361379, DOI: 10.1378/chest.98.1.133.Peer-Reviewed Original ResearchConceptsNasal mask ventilationPost-polio patientsGroup 1 patientsNasal CPAPPoor sleep qualityMask ventilationMixed apneaSleep qualityHypoventilation syndromeRespiratory complaintsPercentage stage 1 sleepRapid eye movement (REM) sleepNasal mechanical ventilationNight-time polysomnographyPost-polio symptomsSignificant O2 desaturationGroup 2 patientsRespiratory muscle weaknessNumber of arousalsEye movement sleepImproved sleep qualityPost-polio syndromeStage 1 sleepTotal sleep timeSlow-wave sleep
1989
The Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels
George C, Millar T, Hanly P, Kryger M. The Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels. Sleep 1989, 12: 345-353. PMID: 2669092, DOI: 10.1093/sleep/12.4.345.Peer-Reviewed Original ResearchConceptsSleep latencyBlood levelsRandom double-blind fashionRapid eye movement (REM) sleepDaytime sleep latencyL-tryptophan's effectsDouble-blind fashionEye movement sleepL-tryptophanSlow-wave sleepL-tryptophan levelsObjective sleepiness measuresKynurenic acidMovement sleepHealthy volunteersWave sleepDrug conditionsSeparate daysSleepSleepiness measuresPlaceboSignificant correlationEssential amino acidsDoseUrine
1981
Sleep Disorders in Chronic Airflow Obstruction
Fleetham J, Kryger M. Sleep Disorders in Chronic Airflow Obstruction. Medical Clinics Of North America 1981, 65: 549-561. PMID: 7017303, DOI: 10.1016/s0025-7125(16)31513-9.Peer-Reviewed Original ResearchConceptsChronic airflow obstructionAirflow obstructionPulmonary hypertensionCardiac arrhythmiasLess rapid eye movement sleepRapid eye movement (REM) sleepSecondary pulmonary hypertensionNocturnal oxygen therapyGas exchange abnormalitiesSleep apnea syndromeEye movement sleepSleep stage changesApnea syndromeOxygen therapyPhysiologic disturbancesMovement sleepSleep disordersSleep profilesPatientsObstructionSleepHypertensionArrhythmiasStage changesSyndrome
1980
Chemical Control of Ventilation and Sleep Arterial Oxygen Desaturation in Patients with COPD1–3
Fleetham J, Mezon B, West P, Bradley C, Anthonisen N, Kryger M. Chemical Control of Ventilation and Sleep Arterial Oxygen Desaturation in Patients with COPD1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 583-9. PMID: 7436124, DOI: 10.1164/arrd.1980.122.4.583.Peer-Reviewed Original ResearchConceptsO2 saturationSleep desaturationVentilatory sensitivityRapid eye movement (REM) sleepNocturnal changesArterial oxygen desaturationLowest O2 saturationHypoxic ventilatory responseArterial O2 saturationEye movement sleepHypoxemic COPDNocturnal desaturationOxygen desaturationLung functionBlood gasesVentilatory responseMovement sleepVentilatory controlPatientsMaximal desaturationSleepDesaturationSleep stagesHypercapniaWakefulness