2017
Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation
Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R. Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation. Arteriosclerosis Thrombosis And Vascular Biology 2017, 37: 1840-1848. PMID: 28798141, PMCID: PMC8036006, DOI: 10.1161/atvbaha.117.308848.Peer-Reviewed Original ResearchConceptsMacrophage activation statesGlutamine accumulationVulnerable plaquesAtherosclerotic lesionsLow-density lipoprotein receptor-null miceF-fluorodeoxyglucose positron emission tomographyReceptor null miceF-fluorodeoxyglucose uptakeHigh-fat dietVessel wall inflammationMacrophage polarization stateEarly promising resultsActivation statePositron emission tomographyMurine peritoneal macrophagesProinflammatory stateInflammatory stateWall inflammationNecrosis factorF-fluorodeoxyglucosePolarization phenotypesInterleukin-4
2014
Molecular imaging of plaque vulnerability
Tavakoli S, Vashist A, Sadeghi MM. Molecular imaging of plaque vulnerability. Journal Of Nuclear Cardiology 2014, 21: 1112-1128. PMID: 25124827, PMCID: PMC4229449, DOI: 10.1007/s12350-014-9959-4.Peer-Reviewed Original Research
2010
Imaging Atherosclerosis and Vulnerable Plaque
Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL. Imaging Atherosclerosis and Vulnerable Plaque. Journal Of Nuclear Medicine 2010, 51: 51s-65s. PMID: 20395341, PMCID: PMC2911776, DOI: 10.2967/jnumed.109.068163.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisClinical Trials as TopicContrast MediaExtracellular MatrixFerric CompoundsFluorodeoxyglucose F18HumansInflammationMagnetic Resonance ImagingNanoparticlesNeovascularization, PathologicRiskThrombosisTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsTotal atherosclerotic burdenAcute cardiovascular eventsAtherosclerotic burdenCardiovascular eventsVascular thrombosisPlaque inflammationMyocardial infarctionPlaque stabilityFibrin depositsVulnerable plaquesHigh riskVasa vasorumPlaque evolutionSame imaging sessionVascular imagingVessel wallImaging sessionClinical translationBiologic processesModalitiesAnatomyExtracellular matrix