Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.
Sofuoglu M, Portoghese P, Takemori A. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal Of Pharmacology And Experimental Therapeutics 1991, 257: 676-80. PMID: 1851833.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesiaAnimalsIndolesMaleMiceMorphinansNaltrexoneNarcotic AntagonistsReceptors, OpioidReceptors, Opioid, deltaConceptsAntinociceptive ED50Antinociceptive actionMorphine sulfateAntinociceptive assaysDelta-opioid receptor agonistDelta opioid receptor subtypesDelta-opioid subtypesOpioid receptor agonistsOpioid receptor subtypesSingle large doseDelta-opioid agonistsPretreatment of animalsOpioid subtypesOpioid agonistsSpinal sitesDifferential antagonismReceptor agonistReceptor subtypesAntinociceptive activityD-Ala2Large doseDSLETDPDPENaltrindoleAntagonist activityCross-tolerance studies in the spinal cord of β-FNA-treated mice provides further evidence for delta opioid receptor subtypes
Sofuoglu M, Portoghese P, Takemori A. Cross-tolerance studies in the spinal cord of β-FNA-treated mice provides further evidence for delta opioid receptor subtypes. Life Sciences 1991, 49: pl153-pl156. PMID: 1658509, DOI: 10.1016/0024-3205(91)90397-t.Peer-Reviewed Original ResearchConceptsDelta opioid receptor subtypesOpioid receptor subtypesAntinociceptive effectReceptor subtypesAntinociceptive ED50 valueDelta-opioid receptor-selective peptideCross-tolerance studiesReceptor-selective peptideSpinal cordTolerance developmentFurther evidenceDPDPEED50 valuesMiceDADLEDAMGOSignificant increaseDSLETSame pretreatmentSubtypesAdministrationSelective peptidesCordFNA