1992
Maintenance of acute morphine tolerance in mice by selective blockage of κ opioid receptors with norbinaltorphimine
Sofuoglu M, Portoghese P, Takemori A. Maintenance of acute morphine tolerance in mice by selective blockage of κ opioid receptors with norbinaltorphimine. European Journal Of Pharmacology 1992, 210: 159-162. PMID: 1318206, DOI: 10.1016/0014-2999(92)90666-r.Peer-Reviewed Original ResearchConceptsMorphine injectionSelective kappa opioid antagonistED50 valuesKappa-opioid antagonistAcute morphine toleranceTail-flick assayDevelopment of toleranceKappa-opioid sitesAntinociceptive ED50 valueNon-pretreated controlsSupraspinal sitesOpioid toleranceMorphine administrationControl miceMorphine sulfateMorphine toleranceOpioid agonistsOpioid antagonistSpinal sitesSingle doseOpioid receptorsOpioid sitesMorphineMiceSelective blockage
1990
Naloxone produces protracted tolerance in mice treated with a single dose of morphine.
Sofuoglu M, Takemori A. Naloxone produces protracted tolerance in mice treated with a single dose of morphine. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 836-40. PMID: 2395115.Peer-Reviewed Original Research