2022
Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone
Novick AM, Duffy KA, Johnson RL, Sammel MD, Cao W, Strasser AA, Sofuoglu M, Kuzma A, Loughead J, Morrow AL, Epperson CN. Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone. Biology Of Sex Differences 2022, 13: 60. PMID: 36274158, PMCID: PMC9590190, DOI: 10.1186/s13293-022-00472-w.Peer-Reviewed Original ResearchConceptsTobacco use disorderProgesterone ratioConversion of progesteroneNicotine withdrawalSmoking cuesTherapeutic effectPlacebo-controlled crossover studySmoking-related outcomesNeural responsesSex-dependent effectsGreater therapeutic benefitDays of abstinenceCrossover studyFemale smokersProgesterone administrationNeurosteroid allopregnanoloneWithdrawal symptomsNicotine effectsWithdrawal severityAllopregnanoloneTherapeutic benefitUse disordersSmoking urgesProgesteroneProgesterone conversionP687. Sex-Dependent Effects of Progesterone on Nicotine Withdrawal and Neural Response to Smoking Cues During Brief Abstinence
Novick A, Duffy K, Johnson R, Sammel M, Cao W, Strasser A, Sofuoglu M, Kuzma A, Loughead J, Epperson C. P687. Sex-Dependent Effects of Progesterone on Nicotine Withdrawal and Neural Response to Smoking Cues During Brief Abstinence. Biological Psychiatry 2022, 91: s368-s369. DOI: 10.1016/j.biopsych.2022.02.924.Peer-Reviewed Original Research
2014
Progesterone for the reduction of cocaine use in post-partum women with a cocaine use disorder: a randomised, double-blind, placebo-controlled, pilot study
Yonkers KA, Forray A, Nich C, Carroll KM, Hine C, Merry BC, Shaw H, Shaw J, Sofuoglu M. Progesterone for the reduction of cocaine use in post-partum women with a cocaine use disorder: a randomised, double-blind, placebo-controlled, pilot study. The Lancet Psychiatry 2014, 1: 360-367. PMID: 25328863, PMCID: PMC4199242, DOI: 10.1016/s2215-0366(14)70333-5.Peer-Reviewed Original ResearchCocaine use disorderCocaine usePostpartum womenPost trialUse disordersPlacebo-controlled pilot trialOral micronized progesteronePositive urine testPost-partum womenGroup differencesSelf-reported daysMultiple brain functionsUse of cocaineMicronized progesteroneObstetrical clinicTherapeutic breakProgesterone replacementAdverse eventsUS National InstitutesProgesterone treatmentUrine testsPilot trialRate of submissionStudy biostatisticianProgesterone
2001
Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women
Sofuoglu M, Babb D, Hatsukami D. Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women. Pharmacology Biochemistry And Behavior 2001, 69: 299-304. PMID: 11420098, DOI: 10.1016/s0091-3057(01)00527-5.Peer-Reviewed Original ResearchConceptsEarly follicular phaseProgesterone treatmentFollicular phaseSmoking behaviorFemale smokersMenstrual cycleProgesterone levelsDose of progesteroneEffect of progesteroneSelf-administration periodMedication treatmentEndogenous estradiolExperimental sessionsExogenous progesteroneNicotine dependenceProgesteroneSubjective effectsSmokersTreatmentEstradiolSubjective responsesCigarettesSecond sessionSubjectsWomen