2023
Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration
MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration. Experimental And Clinical Psychopharmacology 2023, 31: 37-45. PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioDose of nicotineNicotine reinforcementSubjective effectsDiscriminative stimulus effectsHeart rate increaseDoses of nicotineSelf-administration procedureSubjective positive effectsDaily smokersBaseline cravingIntravenous nicotineOvernight abstinenceCigarette cravingDrug effectsMetabolite ratiosStimulus effectsSecondary analysisPlaceboSelf-AdministrationNicotine choiceTobacco productsNicotinePleasurable effectsYoung adults
2022
Modafinil does not reduce cocaine use in methadone-maintained individuals
DeVito EE, Poling J, Babuscio T, Nich C, Carroll KM, Sofuoglu M. Modafinil does not reduce cocaine use in methadone-maintained individuals. Drug And Alcohol Dependence Reports 2022, 2: 100032. PMID: 36310662, PMCID: PMC9615926, DOI: 10.1016/j.dadr.2022.100032.Peer-Reviewed Original ResearchCocaine use disorderCocaine use outcomesOpioid useCognitive behavioral therapyContingency managementCocaine dependenceCognitive functionMethadone-maintained individualsUse outcomesEfficacy of modafinilSelf-reported abstinenceTreatment of CUDStimulant-like effectsPlatform treatmentPercentage of urinesPercent of daysDual opioidModafinil treatmentUse disordersPotential efficacyCocaine useModafinilPlaceboMinimal reportsBehavioral therapy
2021
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDose
2019
Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
1999
Effects of phenytoin on cocaine self-administration in humans1Portions of this report were presented at the 59th Annual Scientific Meeting of the College on the Problems of Drug Dependence, Nashville, June 1997.1
Sofuoglu M, Pentel P, Bliss R, Goldman A, Hatsukami D. Effects of phenytoin on cocaine self-administration in humans1Portions of this report were presented at the 59th Annual Scientific Meeting of the College on the Problems of Drug Dependence, Nashville, June 1997.1. Drug And Alcohol Dependence 1999, 53: 273-275. PMID: 10080053, DOI: 10.1016/s0376-8716(98)00140-9.Peer-Reviewed Original ResearchConceptsEffects of phenytoinSingle oral loading doseOral loading dosePlacebo treatment groupsEffects of cocaineHuman laboratory modelLoading doseSignificant treatment effectCocaine administrationTreatment groupsDrug dependencePhenytoinPilot studyCocaineAnnual Scientific MeetingTreatment effectsSubjective responsesScientific meetingsPlacebo
1998
Effects of cotinine on cigarette self-administration
Hatsukami D, Lexau B, Nelson D, Pentel P, Sofuoglu M, Goldman A. Effects of cotinine on cigarette self-administration. Psychopharmacology 1998, 138: 184-189. PMID: 9718288, DOI: 10.1007/s002130050661.Peer-Reviewed Original ResearchConceptsDoses of cotinineWithdrawal symptomsCigarette withdrawal symptomsEffects of cotinineNicotine serum levelsSelective modulatory effectNicotine withdrawal symptomsNumber of cigarettesEffects of nicotineMetabolite of nicotineSubjective responsesNicotine patchSerum levelsCigarette smokingNicotine intakeModulatory effectsCarbon monoxide levelsCotinineRandomized orderPlaceboBeneficial effectsCigarettesOutcome variablesDosesSymptoms