2019
Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2015
Pilot study of atomoxetine for BUP/NX-maintained patients with co-occurring opioid and ATS use disorder
Schottenfeld R, Chawarski M, Sofuoglu M, Chooi W, Zaharim N, Yasin M, Ahmad I, Jaapar S, Kasinather V. Pilot study of atomoxetine for BUP/NX-maintained patients with co-occurring opioid and ATS use disorder. Drug And Alcohol Dependence 2015, 156: e200. DOI: 10.1016/j.drugalcdep.2015.07.538.Peer-Reviewed Original ResearchTargeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations
Arout CA, Edens E, Petrakis IL, Sofuoglu M. Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations. CNS Drugs 2015, 29: 465-486. PMID: 26142224, DOI: 10.1007/s40263-015-0255-x.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaClinical treatmentChronic painEfficacious treatment regimenTreatment of painOpioid-dependent individualsOpioid-related overdosesAminobutyric acid receptorsDeleterious profileProspective adjuvantOpioid prescriptionsSevere painOpioid analgesicsTreatment regimenNeuroimmune systemPainful stimuliSide effectsLong-term exposurePainAcid receptorsOpioidsClinical usePotential modulatorsHyperalgesiaParadoxical state
1992
δ-Opioid receptor binding in mouse brain: Evidence for heterogeneous binding sites
Sofuoglu M, Portoghese P, Takemori A. δ-Opioid receptor binding in mouse brain: Evidence for heterogeneous binding sites. European Journal Of Pharmacology 1992, 216: 273-277. PMID: 1327813, DOI: 10.1016/0014-2999(92)90370-j.Peer-Reviewed Original ResearchConceptsMouse brainDelta-opioid receptor agonistDelta opioid receptor subtypesOpioid receptor agonistsBrains of miceOpioid receptor subtypesDelta-opioid receptorsΔ-opioid receptorsDelta opioidOpioid receptorsReceptor agonistReceptor subtypesBrainBinding sitesReceptorsOpioidsNaltribenDPDPEDSLETDADLEAgonistsSubtypesMiceEquipotent