2017
Radiation Oncology Considerations in the Management of Mutation Carriers with Breast Cancer
Moran M. Radiation Oncology Considerations in the Management of Mutation Carriers with Breast Cancer. 2017, 151-170. DOI: 10.1007/978-3-319-59198-8_9.Peer-Reviewed Original ResearchBreast cancerMutation carriersRadiation therapyLocal-regional managementPost-mastectomy settingBreast conservation therapyBRCA mutation carriersTreatment management decisionsBRCA mutation statusHereditary breast cancerBreast conservationTNBC patientsConservation therapyBRCA carriersFamily historyMutation statusRadiation therapy deliveryTreatment conceptGenetic testingBRCA genesCancerTherapyStrong associationTherapy deliveryPresent guidelines
2015
Radiation therapy in the locoregional treatment of triple-negative breast cancer
Moran MS. Radiation therapy in the locoregional treatment of triple-negative breast cancer. The Lancet Oncology 2015, 16: e113-e122. PMID: 25752562, DOI: 10.1016/s1470-2045(14)71104-0.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorDecision Support TechniquesDose Fractionation, RadiationFemaleGenetic Predisposition to DiseaseHumansMastectomyNeoplasm Recurrence, LocalPatient SelectionPhenotypePredictive Value of TestsRadiation ToleranceRadiotherapy, AdjuvantRisk AssessmentRisk FactorsTreatment OutcomeTriple Negative Breast Neoplasms
2013
Is Ki-67 Expression Prognostic for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast Conservation Therapy (BCT)?
Hafeez F, Neboori HJ, Harigopal M, Wu H, Haffty BG, Yang Q, Schiff D, Moran MS. Is Ki-67 Expression Prognostic for Local Relapse in Early-Stage Breast Cancer Patients Treated With Breast Conservation Therapy (BCT)? International Journal Of Radiation Oncology • Biology • Physics 2013, 87: 344-348. PMID: 23910708, DOI: 10.1016/j.ijrobp.2013.05.052.Peer-Reviewed Original ResearchConceptsBreast conservation therapyEarly-stage breast cancer patientsHuman epidermal growth factor receptor 2Recurrence-free survivalBreast cancer patientsKi-67 expressionKi-67Clinicopathologic featuresConservation therapyCancer patientsIndependent associationLocoregional recurrence-free survivalDistant metastasis-free survivalLocal relapse-free survivalEpidermal growth factor receptor 2Univariate/multivariate analysisPrognostic clinicopathologic featuresCause-specific survivalHormone receptor statusGrowth factor receptor 2Metastasis-free survivalRelapse-free survivalKi-67 overexpressionSignificant independent associationKi-67 stainingBreast conservation therapy for ductal carcinoma in situ (DCIS): does presentation of disease affect long-term outcomes?
Bai HX, Motwani SB, Higgins SA, Haffty BG, Wilson LD, Lannin DR, Evans SB, Moran MS. Breast conservation therapy for ductal carcinoma in situ (DCIS): does presentation of disease affect long-term outcomes? International Journal Of Clinical Oncology 2013, 19: 460-466. PMID: 23780727, DOI: 10.1007/s10147-013-0575-0.Peer-Reviewed Original ResearchConceptsBreast conservation treatmentLocal relapse-free survivalRelapse-free survivalSigns/symptomsLong-term outcomesDCIS patientsPhysical signs/symptomsTumor sizeER/PR/HERWorse long-term prognosisSignificant overall survival differenceAdjuvant hormone treatmentLong-term prognosisOverall survival differenceBreast conservation therapyLarger tumor sizeStatus of marginsNon-white racePresentation of diseaseMedian followClinicopathological differencesNodal involvementOverall survivalIndependent predictorsConservation therapy
2011
Breast Conservation Therapy for Ductal Carcinoma In Situ (DCIS): Is there a difference in Clinical-Pathologic Features and Long Term Outcomes in Occult, Mammographically-Detected Disease Compared with DCIS Presenting with Physical Findings?
Bai H, Lannin D, Higgins S, Motwani S, Hafty B, Goyal S, Wilson L, Evans S, Moran M. Breast Conservation Therapy for Ductal Carcinoma In Situ (DCIS): Is there a difference in Clinical-Pathologic Features and Long Term Outcomes in Occult, Mammographically-Detected Disease Compared with DCIS Presenting with Physical Findings? International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s245. DOI: 10.1016/j.ijrobp.2011.06.1716.Peer-Reviewed Original ResearchUsing Nodal Ratios to Predict Risk of Regional Recurrences in Patients Treated with Breast Conservation Therapy with 4 or More Positive Lymph Nodes
Castrucci W, Lannin D, Haffty BG, Higgins SA, Moran MS. Using Nodal Ratios to Predict Risk of Regional Recurrences in Patients Treated with Breast Conservation Therapy with 4 or More Positive Lymph Nodes. International Scholarly Research Notices 2011, 2011: 874814. PMID: 22084784, PMCID: PMC3200302, DOI: 10.5402/2011/874814.Peer-Reviewed Original ResearchHigher nodal ratioBreast conservation therapyNodal ratioLymph nodesRegional recurrenceConservation therapyRegional failureN2/N3 patientsPositive axillary lymph nodesPositive lymph nodesAxillary lymph nodesGroup of patientsIntensive systemic therapyN3 statusDistant failureN3 patientsNodal recurrenceSystemic therapyDose escalationEntire cohortRegional nodesBreast cancerInclusion criteriaPrognostic variablesHigh risk
2010
Breast Conservation Therapy and BRCA Status Do Not Predict for Poor Outcomes in Young Women with Early-stage Breast Cancer
Patel A, Goyal S, Moran M, Choi D, Haffty B. Breast Conservation Therapy and BRCA Status Do Not Predict for Poor Outcomes in Young Women with Early-stage Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s213. DOI: 10.1016/j.ijrobp.2010.07.513.Peer-Reviewed Original ResearchDuctal Carcinoma In Situ With Microinvasion: Prognostic Implications, Long-Term Outcomes, and Role of Axillary Evaluation
Parikh RR, Haffty BG, Lannin D, Moran MS. Ductal Carcinoma In Situ With Microinvasion: Prognostic Implications, Long-Term Outcomes, and Role of Axillary Evaluation. International Journal Of Radiation Oncology • Biology • Physics 2010, 82: 7-13. PMID: 20950955, DOI: 10.1016/j.ijrobp.2010.08.027.Peer-Reviewed Original ResearchConceptsDistant relapse-free survivalLocal-regional relapseClinical-pathologic featuresRelapse-free survivalBreast conservation therapyLong-term outcomesOverall survivalAxillary evaluationAxillary metastasesIndependent predictorsDuctal carcinomaCox proportional hazards analysisPresence of microinvasionSurgical axillary evaluationAdjuvant hormonal therapyProportional hazards analysisHormonal therapyAggressive treatmentDistant failureMargin statusSurgical evaluationConservation therapyPrognostic implicationsMean ageUnivariate analysis
2009
Does Compliance with Radiation Therapy Differ in African‐American Patients with Early‐Stage Breast Cancer?1
Sharma C, Harris L, Haffty BG, Yang Q, Moran MS. Does Compliance with Radiation Therapy Differ in African‐American Patients with Early‐Stage Breast Cancer?1. The Breast Journal 2009, 16: 193-196. PMID: 20030649, DOI: 10.1111/j.1524-4741.2009.00874.x.Peer-Reviewed Original ResearchConceptsBreast conservation therapyAA patientsWhite patientsWorse outcomesRadiation therapyAfrican American breast cancer patientsEarly-stage breast cancerAdjuvant chemotherapy regimensMedian radiation doseBreast cancer patientsLarge institutional seriesAfrican American patientsDate of treatmentChemotherapy regimenChemotherapy regimensSame radiation dosesChart reviewInstitutional seriesTherapy differsTreatment breaksConservation therapyCancer patientsBreast cancerMedian numberTreatment daysVascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-stage Breast Cancer Patients Treated with Breast Conservation Therapy
Moran M, Yang Q, Goyal S, Haffty B. Vascular Endothelial Growth Factor as a Prognostic Marker for Local Relapse in Early-stage Breast Cancer Patients Treated with Breast Conservation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: s7-s8. DOI: 10.1016/j.ijrobp.2009.07.043.Peer-Reviewed Original ResearchClinicopathologic Significance of Excision Repair Cross-Complementation 1 Expression in Patients Treated With Breast-Conserving Surgery and Radiation Therapy
Goyal S, Parikh RR, Green C, Schiff D, Moran MS, Yang Q, Haffty BG. Clinicopathologic Significance of Excision Repair Cross-Complementation 1 Expression in Patients Treated With Breast-Conserving Surgery and Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2009, 76: 679-684. PMID: 19464815, DOI: 10.1016/j.ijrobp.2009.02.050.Peer-Reviewed Original ResearchConceptsDistant metastasis-free survivalHuman epidermal growth factor receptor 2Cause-specific survivalLower T stageMetastasis-free survivalBreast conservation therapyERCC-1 expressionERCC1 expressionAdjuvant chemotherapyHormonal therapyER positivityOverall survivalT stageConservation therapyProgesterone receptorBreast cancerEstrogen receptorNodal negativityRadiation therapyWorse distant metastasis-free survivalEarly-stage breast cancer patientsLocoregional recurrence-free survivalEarly-stage breast cancerEpidermal growth factor receptor 2Adjuvant hormonal therapyClinical-Pathologic Features and Long-Term Outcomes of Tubular Carcinoma of the Breast Compared With Invasive Ductal Carcinoma Treated With Breast Conservation Therapy
Liu GF, Yang Q, Haffty BG, Moran MS. Clinical-Pathologic Features and Long-Term Outcomes of Tubular Carcinoma of the Breast Compared With Invasive Ductal Carcinoma Treated With Breast Conservation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: 1304-1308. PMID: 19386432, DOI: 10.1016/j.ijrobp.2008.12.070.Peer-Reviewed Original ResearchConceptsClinical-pathologic featuresInvasive ductal carcinomaRelapse-free survivalBreast conservation therapyLong-term outcomesConservation therapyTC cohortTumor RegistryDuctal carcinomaTubular carcinomaInstitutional experienceBreast cancer-related deathsNodal relapse-free survivalInstitution's tumor registryCentral pathology reviewHormone receptor positivityCancer-related deathPT1 diseaseConservative surgeryPN0 diseasePathology reviewClinical outcomesDistant metastasisRare subtypeRadiation therapy
2008
Long‐term outcomes and clinicopathologic differences of African‐American versus white patients treated with breast conservation therapy for early‐stage breast cancer
Moran MS, Yang Q, Harris LN, Jones B, Tuck DP, Haffty BG. Long‐term outcomes and clinicopathologic differences of African‐American versus white patients treated with breast conservation therapy for early‐stage breast cancer. Cancer 2008, 113: 2565-2574. PMID: 18816610, DOI: 10.1002/cncr.23881.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma, MucinousAdultAntineoplastic AgentsBlack or African AmericanBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularCohort StudiesCombined Modality TherapyFemaleFollow-Up StudiesHumansLymph NodesLymphatic MetastasisMastectomyNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRadiotherapy DosageSurvival RateTreatment OutcomeWhite PeopleConceptsBreast conservation therapyLymph node recurrenceAA patientsWhite patientsAA womenNode recurrenceConservation therapyClinicopathologic differencesEarly-stage breast cancerChemotherapy/radiotherapyEarly-stage diseaseSurgical margin statusLong-term outcomesP53 expression statusBreast recurrenceOverall survivalIndependent predictorsLocal recurrenceLymph nodesMargin statusClinicopathologic featuresDistant metastasisN classificationMore estrogenBreast cancerPrognostic Implications of Mammographically Occult, Early Stage Breast Cancer Patients Treated with Breast Conservation Therapy
Yang T, Yang Q, Haffty B, Moran M. Prognostic Implications of Mammographically Occult, Early Stage Breast Cancer Patients Treated with Breast Conservation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2008, 72: s92. DOI: 10.1016/j.ijrobp.2008.06.976.Peer-Reviewed Original Research
2007
Using Nodal Ratios to Predict the Risk of In-Field Regional Recurrences in Patients Treated With Breast Conservation Therapy in Patients With 4 or More Positive Lymph Nodes
Castrucci W, Haffty B, Moran M. Using Nodal Ratios to Predict the Risk of In-Field Regional Recurrences in Patients Treated With Breast Conservation Therapy in Patients With 4 or More Positive Lymph Nodes. International Journal Of Radiation Oncology • Biology • Physics 2007, 69: s212. DOI: 10.1016/j.ijrobp.2007.07.1179.Peer-Reviewed Original Research