2022
Shear-mediated ALK5 expression regulates endothelial activation
Pang K, Ghim M, Sarathchandra P, Warboys C, Yacoub M, Chester A, Weinberg P. Shear-mediated ALK5 expression regulates endothelial activation. Biochemical And Biophysical Research Communications 2022, 642: 90-96. PMID: 36566567, DOI: 10.1016/j.bbrc.2022.12.058.Peer-Reviewed Original ResearchConceptsBlood flowCalcific aortic valve diseaseAortic valve diseaseHuman umbilical vein endothelial cell monolayersEndothelial-leukocyte adhesionALK5 kinase activityCardiovascular disease pathologyPotential therapeutic targetAortic valve tissueEndothelial dysfunctionValve diseaseALK5 expressionEndothelial activationFurther mechanistic investigationsEndothelial cell monolayersPorcine aortic valve tissuePathophysiological changesOvert diseaseAortic sidePathological changesTherapeutic targetVentricular sideLeukocyte adhesionMonocyte adhesionSmad2 phosphorylation
2021
Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor
Pang K, Ghim M, Liu C, Tay H, Fhu C, Chia R, Qiu B, Sarathchandra P, Chester A, Yacoub M, Wilkinson F, Weston R, Warboys C, Hou H, Weinberg P, Wang X. Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Frontiers In Cell And Developmental Biology 2021, 9: 706143. PMID: 34291056, PMCID: PMC8288075, DOI: 10.3389/fcell.2021.706143.Peer-Reviewed Original ResearchTumor necrosis factor receptor 1Critical limb ischemiaSera of patientsEndothelial activationEndothelial cellsLRG1 expressionElevated serum concentrationsPotential therapeutic roleLeucine-Rich αTumor necrosis factorTNF-α receptorWild-type miceEndothelial cell activationNecrosis factor receptor 1Role of LRG1NF-κB activationNF-κB signalingFactor receptor 1STNFR1 concentrationCLI patientsLimb ischemiaSerum concentrationsHealthy controlsInflammatory diseasesTherapeutic role
2018
LRG1 is a novel regulator of endothelial activation and is shear dependent: A Potential therapeutic target?
Pang K, Fhu C, Ghim M, Tay H, Hou H, Lu Q, Warboys C, Wang X, Weinberg P. LRG1 is a novel regulator of endothelial activation and is shear dependent: A Potential therapeutic target? Atherosclerosis 2018, 275: e37. DOI: 10.1016/j.atherosclerosis.2018.06.094.Peer-Reviewed Original Research53LRG1 is a novel regulator of endothelial activation and is shear dependent: a potential therapeutic target?
Pang K, Fhu C, Ghim M, Tay H, Hou H, Lu Q, Warboys C, Wang X, Weinberg P. 53LRG1 is a novel regulator of endothelial activation and is shear dependent: a potential therapeutic target? Cardiovascular Research 2018, 114: s13-s14. DOI: 10.1093/cvr/cvy060.023.Peer-Reviewed Original Research