Featured Publications
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma
Lozano AX, Chaudhuri AA, Nene A, Bacchiocchi A, Earland N, Vesely MD, Usmani A, Turner BE, Steen CB, Luca BA, Badri T, Gulati GS, Vahid MR, Khameneh F, Harris PK, Chen DY, Dhodapkar K, Sznol M, Halaban R, Newman AM. T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma. Nature Medicine 2022, 28: 353-362. PMID: 35027754, PMCID: PMC8866214, DOI: 10.1038/s41591-021-01623-z.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsImmune-related adverse eventsT-cell characteristicsIrAE developmentBlood samplesSevere immune-related adverse eventsAnti-PD-1 monotherapyCombination immune checkpoint inhibitorsT-cell receptor sequencingT cell abundanceCell receptor sequencingOrgan system involvementPeripheral blood samplesIrAE onsetCheckpoint inhibitorsAdverse eventsCheckpoint blockadeRNA sequencingTCR clonalityCombination therapyPatient cohortSystem involvementClinical managementTCR diversityImmunological state
2020
Paradoxical eruptions to targeted therapies in dermatology: A systematic review and analysis
Murphy MJ, Cohen JM, Vesely MD, Damsky W. Paradoxical eruptions to targeted therapies in dermatology: A systematic review and analysis. Journal Of The American Academy Of Dermatology 2020, 86: 1080-1091. PMID: 33307146, DOI: 10.1016/j.jaad.2020.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesCytokinesDermatologyHumansInterleukin-23PsoriasisRetrospective StudiesTumor Necrosis Factor-alphaConceptsParadoxical reactionSystematic reviewNecrosis factor α inhibitorsTumor necrosis factor αSpectrum of manifestationsNecrosis factor αAntibody-based therapiesInterleukin-12/23IL-23IL-12/23Clinical featuresCutaneous reactionsEczematous eruptionInflammatory disordersProinflammatory cytokinesΑ inhibitorsRetrospective analysisIL-4RαFactor αPotential mechanismsDermatologyTherapyInhibitorsAntibodiesReaction patterns