2021
Transcriptomics of the depressed and PTSD brain
Zhang J, Kaye AP, Wang J, Girgenti MJ. Transcriptomics of the depressed and PTSD brain. Neurobiology Of Stress 2021, 15: 100408. PMID: 34703849, PMCID: PMC8524242, DOI: 10.1016/j.ynstr.2021.100408.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHigh-throughput transcriptomic methodsSingle-cell RNA sequencingCell RNA sequencingLarge genomic datasetsCommon molecular pathwaysTranscriptomic approachTranscriptional programsTranscriptome studiesStress adaptationTranscriptomic methodsRNA sequencingGenomic datasetsSurvival mechanismMolecular pathwaysOrganismsPTSD brainsTranscriptomeTranscriptomicsAdaptationNeurobiology of stressStressSequencingPathwayCentral questionNeurobiologists
2019
Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes
Girgenti MJ, Wohleb ES, Mehta S, Ghosal S, Fogaca MV, Duman RS. Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes. Translational Psychiatry 2019, 9: 292. PMID: 31712551, PMCID: PMC6848179, DOI: 10.1038/s41398-019-0642-z.Peer-Reviewed Original ResearchConceptsFluorescence-activated cell sortingInitiation factor 2Distinct transcriptome profilesTranslational machineryTranscriptome profilesEnriched pathwaysTranscriptional pathwaysTranscriptional profilesRNA sequencingDepressive-like behaviorSST interneuronsKey pathwaysChronic stressInterneuron subtypesSex-specific differencesPrefrontal cortexCell sortingSignificant dysregulationFactor 2PathwayStress-induced depressive-like behaviorDecreased expressionReporter miceGrowth factorNon-stressed females