2020
Stress and Its Impact on the Transcriptome
Girgenti MJ, Pothula S, Newton SS. Stress and Its Impact on the Transcriptome. Biological Psychiatry 2020, 90: 102-108. PMID: 33637305, PMCID: PMC8213869, DOI: 10.1016/j.biopsych.2020.12.011.Peer-Reviewed Original ResearchConceptsTranscriptomic dysregulationMajor gene expression changesGene expression changesDevelopmental time pointsAnimal modelsGenomic studiesNeuropsychiatric disordersTranscriptomic methodsAnimal kingdomComparable animal modelsGene expressionExpression changesEarly life stressPhenotypic signaturesSex-specific changesTransgenerational impactTranscriptomeSingle cellsEntire brain regionsPowerful approachDiseased brainBrain regionsChronic stressMolecular profileSame disorder
2017
Transcriptome Alterations in Posttraumatic Stress Disorder
Girgenti MJ, Duman RS. Transcriptome Alterations in Posttraumatic Stress Disorder. Biological Psychiatry 2017, 83: 840-848. PMID: 29128043, DOI: 10.1016/j.biopsych.2017.09.023.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderNext-generation sequencing technologiesAberrant gene expressionGene expression changesAmount of transcriptsGene expression studiesGene profiling studiesAlternative splicingTranscriptome alterationsTranscriptomic technologiesRNA sequencingSequencing technologiesTranscript identificationExpression studiesGene expressionExpression changesStress disorderBlood of patientsCellular mechanismsPeripheral blood cellsProfiling studiesHuman peripheral bloodPeripheral bloodLifetime prevalenceGeneral population