Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD
Logue MW, Zhou Z, Morrison FG, Wolf EJ, Daskalakis NP, Chatzinakos C, Georgiadis F, Labadorf AT, Girgenti MJ, Young KA, Williamson DE, Zhao X, Grenier JG, Group T, Huber BR, Miller MW. Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD. Neurobiology Of Stress 2021, 15: 100398. PMID: 34646915, PMCID: PMC8498459, DOI: 10.1016/j.ynstr.2021.100398.Peer-Reviewed Original ResearchPrefrontal cortexVentromedial prefrontal cortexDepression casesHistory of PTSDDepression-associated genesImmune-related networkBrain BankImmune regulationGene expressionIndependent cohortBrain regionsEvidence of replicationPTSD casesMultiple testing correctionImmune genesPTSDCo-expression network analysisCortexEffect sizeUpstream regulatorRNA sequencingRecent studiesGenetic modelsExpressionCandidate gene analysis