2024
Blood DNA Methylation Is Associated with Histopathological Changes in Patients with Lupus Nephritis
Bakhoum C, Demkowicz P, Kumar D, Ix J, Moledina D, Bakhoum M. Blood DNA Methylation Is Associated with Histopathological Changes in Patients with Lupus Nephritis. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024bqw1nbby. DOI: 10.1681/asn.2024bqw1nbby.Peer-Reviewed Original ResearchRetinal Ischemic Perivascular Lesions Are Associated With Stroke in Individuals With Atrial Fibrillation.
Bakhoum C, Au A, Bousquet E, Matesva M, Singer M, Jayaraj C, Romero-Morales V, Somisetty S, Santina A, Bajar B, DeMaria A, Goldbaum M, Meadows J, Spatz E, Sarraf D, Bakhoum M. Retinal Ischemic Perivascular Lesions Are Associated With Stroke in Individuals With Atrial Fibrillation. Journal Of The American Heart Association 2024, 13: e035079. PMID: 39190603, DOI: 10.1161/jaha.123.035079.Peer-Reviewed Original ResearchStandardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop
Chew E, Burns S, Abraham A, Bakhoum M, Beckman J, Chui T, Finger R, Frangi A, Gottesman R, Grant M, Hanssen H, Lee C, Meyer M, Rizzoni D, Rudnicka A, Schuman J, Seidelmann S, Tang W, Adhikari B, Danthi N, Hong Y, Reid D, Shen G, Oh Y. Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop. Nature Reviews Cardiology 2024, 1-17. PMID: 39039178, DOI: 10.1038/s41569-024-01060-8.Peer-Reviewed Original ResearchPrimary care dataMicrovascular diseaseDiverse at-risk populationsCardiovascular diseaseRetinal biomarkersOphthalmic imaging techniqueRisk of cardiovascular diseaseRetinal microvascular diseaseIndividual-level riskAt-risk populationsMacrovascular risk factorsSystemic vascular bedsDevelopment of microvascular diseaseCoronary artery diseaseHealth workersCare dataLifestyle factorsMonitoring of systemic diseasesRetinal imaging biomarkersNational HeartVascular dementiaBlood InstituteHeart failureMultidisciplinary networkSystemic diseaseSystems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
Trogdon M, Abbott K, Arang N, Lande K, Kaur N, Tong M, Bakhoum M, Gutkind J, Stites E. Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation. Npj Systems Biology And Applications 2024, 10: 75. PMID: 39013872, PMCID: PMC11252164, DOI: 10.1038/s41540-024-00400-1.Peer-Reviewed Original ResearchConceptsSignaling networksMathematical models of biochemical reaction networksModels of biochemical reaction networksG-proteinCell signaling networksDisease-causing mutationsComputational systems biologyBiochemical reaction networksDownstream pathway activationSignaling phenotypeSystems biologyBioinformatics analysisGPCR signalingMutationsCo-occurring mutationsOncogenic mutationsPathway activationDiscovery toolPathwayReaction networkSignalCYSLTR2 mutationsDiscoveryPhenotypeMutually-exclusiveRetinal Ischemic Perivascular Lesions Are Associated With Myocardial Infarction in Patients With Coronary Artery Disease
Bousquet E, Santina A, Au A, Somisetty S, Abraham N, Voichanski S, Estawro R, Fouad Y, Romero-Morales V, Bakhoum M, Sarraf D. Retinal Ischemic Perivascular Lesions Are Associated With Myocardial Infarction in Patients With Coronary Artery Disease. American Journal Of Ophthalmology 2024, 264: 224-228. PMID: 38552932, DOI: 10.1016/j.ajo.2024.03.017.Peer-Reviewed Original ResearchCoronary artery diseaseSD-OCTBody mass indexMyocardial infarctionAssociated with MIMacular spectral-domain optical coherence tomographyMass indexPerivascular lesionsSpectral-domain optical coherence tomographyArtery diseaseSmoking statusMultivariate logistic regression analysisMedical management of coronary artery diseaseManagement of coronary artery diseaseOptical coherence tomographyNon-MI groupHistory of MIAssociated with myocardial infarctionLogistic regression analysisPotential clinical utilityConsecutive patientsOCT scansCoherence tomographyOdds ratioMedical management
2023
Differentiating Lupus Nephritis Classes Using Peripheral Blood DNA Methylation
Bakhoum C, Faulkner S, Ix J, Moledina D, Bakhoum M. Differentiating Lupus Nephritis Classes Using Peripheral Blood DNA Methylation. Journal Of The American Society Of Nephrology 2023, 34: 243-243. DOI: 10.1681/asn.20233411s1243b.Peer-Reviewed Original Research