2017
Elevated brain derived neurotrophic factor levels in plasma reflect in vivo functional viability of infused mesenchymal stem cells for stroke in rats.
Nakamura H, Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Namioka T, Namioka A, Onodera R, Suzuki J, Nagahama H, Mikami T, Wanibuchi M, Kocsis JD, Honmou O. Elevated brain derived neurotrophic factor levels in plasma reflect in vivo functional viability of infused mesenchymal stem cells for stroke in rats. Journal Of Neurosurgical Sciences 2017, 63: 42-49. PMID: 28181779, DOI: 10.23736/s0390-5616.17.03989-3.Peer-Reviewed Original ResearchConceptsInfused mesenchymal stem cellsMiddle cerebral artery occlusionVivo functional viabilityBDNF levelsMSC infusionMesenchymal stem cellsMCAO inductionPlasma BDNFNeurotrophic factorLesion volumeMSC groupMiddle cerebral artery occlusion modelPermanent middle cerebral artery occlusionCerebral infarction rat modelBrain BDNF levelsElicit functional recoveryIntravenous MSC infusionLimb placement testNeurotrophic factor levelsPlasma BDNF levelsCerebral artery occlusionArtery occlusion modelRat stroke modelFunctional viabilityImmunosorbent assay analyses
2016
Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats
Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Suzuki J, Tateyama D, Oka S, Namioka T, Namioka A, Onodera R, Mikami T, Wanibuchi M, Kakizawa M, Ishiai S, Kocsis JD, Honmou O. Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats. Physical Therapy 2016, 96: 1791-1798. PMID: 27174259, DOI: 10.2522/ptj.20150504.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusionIntravenous infusionDaily rehabilitationMesenchymal stem cellsMSC infusionFunctional outcomePermanent middle cerebral artery occlusionLimb placement testCerebral artery occlusionRat stroke modelRat MCAO modelIntraluminal vascular occlusionMagnetic resonance imagingStem cellsAdult bone marrowArtery occlusionCerebral ischemiaMCAO modelVascular occlusionFunctional improvementLesion volumeTherapy groupTherapeutic effectStroke modelGroup 2