2022
Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model
Maeda S, Kawamura T, Sasaki M, Shimamura K, Shibuya T, Harada A, Honmou O, Sawa Y, Miyagawa S. Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. Scientific Reports 2022, 12: 16986. PMID: 36216855, PMCID: PMC9551049, DOI: 10.1038/s41598-022-18485-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowDisease Models, AnimalGreen Fluorescent ProteinsHindlimbInfusions, IntravenousIschemiaLower ExtremityMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNeovascularization, PhysiologicPerfusionPeripheral Vascular DiseasesRatsRats, Sprague-DawleyVascular Endothelial Growth Factor AConceptsIntravenous infusionVascular endothelial growth factorMesenchymal stem cellsTissue perfusionHindlimb ischemia modelRat hindlimb ischemia modelIschemia modelCell groupsFemoral artery removalIschemia animal modelStem cellsHindlimb muscle tissueBone marrow-derived mesenchymal stem cellsEndothelial growth factorMarrow-derived mesenchymal stem cellsMSC infusionHistological findingsIschemic limbsHindlimb ischemiaCell delivery methodsIschemic hindlimbSprague-DawleyCapillary densityAnimal modelsInfusion
2021
Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis
Magota H, Sasaki M, Kataoka-Sasaki Y, Oka S, Ukai R, Kiyose R, Onodera R, Kocsis JD, Honmou O. Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis. Molecular Brain 2021, 14: 76. PMID: 33962678, PMCID: PMC8103621, DOI: 10.1186/s13041-021-00787-6.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisAdministration of MSCsSingle infusionMesenchymal stem cellsMotor functionGait abilityDisease progressionMotor neuronsRat modelLateral sclerosisBlood-spinal cord barrierSOD1G93A rat modelSpinal cord degenerateVehicle infusion groupHind limb functionALS rat modelStem cellsLimb functionVehicle infusionFatal disorderSurvival periodTherapeutic effectLocomotor activityInfusionProgressive deterioration
2020
Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
Nakazaki M, Oka S, Sasaki M, Kataoka-Sasaki Y, Nagahama H, Hashi K, Kocsis JD, Honmou O. Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells. Heliyon 2020, 6: e05833. PMID: 33392407, PMCID: PMC7773587, DOI: 10.1016/j.heliyon.2020.e05833.Peer-Reviewed Original ResearchHypertensive rat modelIntravenous infusionMesenchymal stem cellsRat modelGrowth factor-β1Forkhead box O1Stem cellsRenal dysfunctionMSC infusionSpontaneous hypertensionHypertensive ratsFactor-β1Survival rateTherapeutic efficacyInfusionBox O1Gene expression analysisHypertensionCellsDysfunctionMicrovascularKidneyRatsLiverExpression analysis
2018
Intravenous Infusion of Mesenchymal Stem Cells Alters Motor Cortex Gene Expression in a Rat Model of Acute Spinal Cord Injury
Oshigiri T, Sasaki T, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Oka S, Morita T, Hirota R, Yoshimoto M, Yamashita T, Hashimoto-Torii K, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Alters Motor Cortex Gene Expression in a Rat Model of Acute Spinal Cord Injury. Journal Of Neurotrauma 2018, 36: 411-420. PMID: 29901416, PMCID: PMC6352512, DOI: 10.1089/neu.2018.5793.Peer-Reviewed Original ResearchConceptsSpinal cord injuryInfused mesenchymal stem cellsMesenchymal stem cellsCord injuryIntravenous infusionFunctional improvementAcute spinal cord injuryBlood-spinal cord barrierGene expression signaturesAxonal sproutingFunctional recoveryMotor cortexSystemic infusionVehicle infusionSpinal cordRat modelTherapeutic mechanismImproved functionInfusionTranscription-polymerase chain reaction dataPearson correlation analysisBehavioral functionsExpression signaturesGenome-wide RNA profilingRecent evidence
2017
Mesenchymal Stem Cells
Sasaki M, Honmou O. Mesenchymal Stem Cells. 2017, 147-156. DOI: 10.1007/978-4-431-56059-3_12.Peer-Reviewed Original ResearchIntravenous infusionMesenchymal stem cellsAdult human bone marrowHuman bone marrowAnimal modelsBone marrowInfused mesenchymal stem cellsHuman stroke patientsSpinal cord injuryInitial clinical studiesInitial human studiesStem cellsAxonal sproutingCerebral strokeStroke patientsCord injuryFunctional improvementClinical studiesTherapeutic effectStroke modelHuman studiesInfusionStrokeMarrowHuman mesenchymal stem cells
2009
Development of a stroke model in the nonhuman primate and a safety study of IV infusion of human mesenchymal stem cells
Sasaki M, Radtke C, Honmou O, Houkin K, Kocsis J. Development of a stroke model in the nonhuman primate and a safety study of IV infusion of human mesenchymal stem cells. Neuroscience Research 2009, 65: s127. DOI: 10.1016/j.neures.2009.09.613.Peer-Reviewed Original Research