2006
Molecular Reconstruction of Nodes of Ranvier after Remyelination by Transplanted Olfactory Ensheathing Cells in the Demyelinated Spinal Cord
Sasaki M, Black JA, Lankford KL, Tokuno HA, Waxman SG, Kocsis JD. Molecular Reconstruction of Nodes of Ranvier after Remyelination by Transplanted Olfactory Ensheathing Cells in the Demyelinated Spinal Cord. Journal Of Neuroscience 2006, 26: 1803-1812. PMID: 16467529, PMCID: PMC2605396, DOI: 10.1523/jneurosci.3611-05.2006.Peer-Reviewed Original ResearchConceptsDemyelinated spinal cordSpecific membrane domainsSpinal cordVoltage-gated ion channelsGreen fluorescent proteinTransplanted Olfactory Ensheathing CellsMature NodalMembrane domainsSpinal cord demyelinationOlfactory Ensheathing CellsVivo electrophysiological recordingsFluorescent proteinJuxtaparanodal domainsMolecular reconstructionIon channelsMature nodesRemyelinated axonsExtensive remyelinationUninjured axonsKv channelsDemyelinated axonsDonor ratsCentral axonsGlial cellsJuxtaparanodal region
2004
Identified Olfactory Ensheathing Cells Transplanted into the Transected Dorsal Funiculus Bridge the Lesion and Form Myelin
Sasaki M, Lankford KL, Zemedkun M, Kocsis JD. Identified Olfactory Ensheathing Cells Transplanted into the Transected Dorsal Funiculus Bridge the Lesion and Form Myelin. Journal Of Neuroscience 2004, 24: 8485-8493. PMID: 15456822, PMCID: PMC2605369, DOI: 10.1523/jneurosci.1998-04.2004.Peer-Reviewed Original ResearchConceptsSprague-DawleyOlfactory bulbTransection siteMyelinated axonsLesion zoneForm myelinOpen field locomotor behaviorAdult olfactory bulbTransection lesionTransplantation groupPattern of repairSD ratsSpinal cordLesion areaLesionsCellular elementsImproved locomotionAxonsLocomotor behaviorMyelinGFP cellsGreen fluorescent proteinCellsAnti-GFP antibodyDiscrete bundles