2018
Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction.
Namioka T, Namioka A, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction. Journal Of Neurosurgery 2018, 131: 1289-1296. PMID: 30485210, DOI: 10.3171/2018.5.jns18140.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionCerebral infarctionIntravenous infusionMesenchymal stem cellsChronic phaseRat modelBone marrowBlood-brain barrier integrityCerebral artery occlusionVehicle-treated groupChronic cerebral infarctionPhase of strokeStem cellsAdult bone marrowArtery occlusionBBB leakageMotor recoveryFunctional recoveryIschemic volumeFunctional outcomeSystemic infusionBrain parenchymaFunctional improvementSystemic injectionClinical studiesPreservation of interhemispheric cortical connections through corpus callosum following intravenous infusion of mesenchymal stem cells in a rat model of cerebral infarction
Nagahama H, Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Namioka T, Namioka A, Oka S, Onodera R, Suzuki J, Sasaki Y, Kocsis JD, Honmou O. Preservation of interhemispheric cortical connections through corpus callosum following intravenous infusion of mesenchymal stem cells in a rat model of cerebral infarction. Brain Research 2018, 1695: 37-44. PMID: 29802840, DOI: 10.1016/j.brainres.2018.05.033.Peer-Reviewed Original ResearchConceptsInterhemispheric cortical connectionsCorpus callosumIntravenous infusionMesenchymal stem cellsDiffusion tensor imagingMotor cortexFunctional improvementCortical connectionsAdeno-associated virusRat middle cerebral artery occlusion stroke modelMiddle cerebral artery occlusion stroke modelContralateral motor cortexBlood-brain barrierMotor cortex connectivityVehicle-infused groupMRI diffusion tensor imagingPotential therapeutic mechanismNeuroanatomical tracing techniquesStem cellsCerebral infarctionInflammatory infiltrationAnatomical restorationCerebral strokeFunctional recoveryNeurotrophic factor
2014
Possible neural plasticity detected by fMRI associates with improved motor function following intravenous injection of mesenchymal stem cells in a rat stroke model
Nakazaki M, Suzuki J, Sasaki M, Oka S, Sasaki Y, Honmou O. Possible neural plasticity detected by fMRI associates with improved motor function following intravenous injection of mesenchymal stem cells in a rat stroke model. Cerebral Blood Flow And Metabolism (Japanese Journal Of Cerebral Blood Flow And Metabolism) 2014, 25: 67. DOI: 10.16977/cbfm.25.2_67.Peer-Reviewed Original ResearchFunctional recoveryMesenchymal stem cellsLesion volumeSensorimotor cortexMotor functionInfused groupIschemic stroke model ratsStroke model ratsGreater functional recoveryImproved motor functionImproved functional outcomesAutologous mesenchymal stem cellsRat stroke modelRandomized-clinical trialFMRI patternsStem cellsCerebral infarctionStroke patientsFunctional outcomeIntravenous transplantationModel ratsMSCs groupFunctional deficitsSomatosensory cortexClinical trials