Effects of combined 17β-estradiol and progesterone on weight and blood pressure in postmenopausal women of the REPLENISH trial
Black D, Minkin M, Graham S, Bernick B, Mirkin S. Effects of combined 17β-estradiol and progesterone on weight and blood pressure in postmenopausal women of the REPLENISH trial. Menopause The Journal Of The North American Menopause Society 2020, 28: 32-39. PMID: 32932401, PMCID: PMC7769186, DOI: 10.1097/gme.0000000000001659.Peer-Reviewed Original ResearchConceptsE2/P4Diastolic blood pressureSystolic blood pressureBlood pressurePostmenopausal womenREPLENISH trialMonth 12Treatment-emergent adverse eventsWeight gainTwelve-month useHealthy postmenopausal womenSevere vasomotor symptomsBody mass indexAdverse eventsVasomotor symptomsMass indexEfficacy profileWomenBaselineHypertensionPlaceboUterusTrialsImportant changesPrevious findings