2024
Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice
Ormiston K, Melink Z, Andridge R, Lustberg M, DeVries A, Murphy K, Emmers K, Ziouzenkova O, Belury M, Orchard T. Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice. Brain Behavior And Immunity 2024, 123: 370-382. PMID: 39313165, DOI: 10.1016/j.bbi.2024.09.021.Peer-Reviewed Original ResearchHOMA-IRChemotherapy-related cognitive impairmentHigh-fatDietary eicosapentaenoic acidDocosahexaenoic acidBlood-brain barrier regulationDoxorubicin-based chemotherapyFemale C57BL/6 miceLF groupEicosapentaenoic acidBody fat lossLow-fat (LFHF dietNeuroinflammatory gene expressionLipid metabolismMultiple genesReduction of oxidative stressAlterations of glucoseFat (LFHigh-fat dietGene expressionOvariectomized miceC57BL/6 miceChemotherapy agentsBreast cancerLow sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy
Ormiston K, Fitzgerald J, Andridge R, Lustberg M, DeVries A, Orchard T. Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy. Nutrition Research 2024, 131: 39-53. PMID: 39368285, DOI: 10.1016/j.nutres.2024.09.004.Peer-Reviewed Original ResearchLiver lipid contentMouse model of chemotherapyLipid contentBody weightLong-term memorySucrose dietLow-sucrose dietDocosahexaenoic acidInsulin resistanceChemotherapy-related cognitive impairmentMouse modelEffects of EPA+DHADoxorubicin-based chemotherapyFemale C57BL/6 miceImpact of chemotherapyAltered insulin resistanceNegatively impacts quality of lifeInsulin resistance scoreDietResistance scoreLower sucrose consumptionEPA+DHARandomized to 1Affective side effectsEicosapentaenoic acid + docosahexaenoic acid
2022
The Effects of Chemotherapy on Circulating Plasma Omega-9, Omega-3 Fatty Acids and Plasmalogen in Breast Cancer Patients
Bennouna D, Orchard T, Lustberg M, Kopec R. The Effects of Chemotherapy on Circulating Plasma Omega-9, Omega-3 Fatty Acids and Plasmalogen in Breast Cancer Patients. Current Developments In Nutrition 2022, 6: 6009237. PMCID: PMC9193887, DOI: 10.1093/cdn/nzac052.004.Peer-Reviewed Original ResearchPlasma concentrationsCognitive impairmentLong-term cognitive impairmentNutritional targetsDocosahexaenoic acidNervonic acidEicosapentaenoic acidOmega-3 fatty acidsNeo-adjuvant chemotherapyBreast cancer patientsEffect of chemotherapyBreast cancer chemotherapyFatty acidsBreast cancer treatmentHippocampal concentrationsDietary interventionSolid tumor treatmentCancer patientsChemotherapy treatmentFatty acid concentrationsObjective biomarkersBreast cancerImpact of visitsChemotherapyMead acid
2021
Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy
Ormiston K, Gaudier-Diaz MM, TinKai T, Fitzgerald J, Cole RM, Andridge R, Lustberg M, DeVries AC, Orchard T. Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy. Nutritional Neuroscience 2021, 25: 2650-2658. PMID: 34772330, PMCID: PMC9095756, DOI: 10.1080/1028415x.2021.1998296.Peer-Reviewed Original ResearchConceptsAlpha-linolenic acidDietary alpha-linolenic acidBrain PUFAsMouse modelDocosahexaenoic acidEicosapentaenoic acidLiver PUFABrain nOmega-3 fatty acidsChemotherapy-treated miceHigh ALA dietLow ALA intakeBrain fatty acidsUseful surrogate markerFatty acidsLiver docosahexaenoic acidToxic side effectsLiver fatty acidALA intakeNeurotrophic markersALA dietDHA dietSurrogate markerLower brainSide effects
2020
Effects of Omega-3 Fatty Acids on Brain Fatty Acids and Associations with Glucose Metabolism and Anxiety-Like Behavior in an Ovariectomized Mouse Model of Chemotherapy
Ormiston K, Phuwamongkolwiwat-Chu P, Fitzgerald J, Tinkai T, Lustberg M, DeVries A, Andridge R, Orchard T. Effects of Omega-3 Fatty Acids on Brain Fatty Acids and Associations with Glucose Metabolism and Anxiety-Like Behavior in an Ovariectomized Mouse Model of Chemotherapy. Current Developments In Nutrition 2020, 4: nzaa057_044. PMCID: PMC7257389, DOI: 10.1093/cdn/nzaa057_044.Peer-Reviewed Original ResearchAnxiety-like behaviorBrain AADietary eicosapentaenoic acidHigh-sucrose dietDHA dietSerum insulinDocosahexaenoic acidOmega-3Low omega-3Eicosapentaenoic acidChemotherapy injectionsInsulin resistanceMouse modelGlucose metabolismSucrose dietOmega-3 fatty acidsBrain fatty acidsHomeostatic model assessmentLower HOMA-IRDiet fed miceHigher serum insulinOvariectomized mouse modelFatty acidsOvariectomized C57BL/6 miceMore anxiety-like behavior
2019
An omega-3 Fatty Acid Enriched Diet Reduces Anxiety-like Behavior While High Dietary Sucrose During Chemotherapy Increases Anxiety-like Behavior in Mice (P14-023-19)
Ormiston K, Orchard T, DeVries A, Phuwamongkolwiwat P, Li J, Andridge R, Fitzgerald J, Tinkai T, Lustberg M. An omega-3 Fatty Acid Enriched Diet Reduces Anxiety-like Behavior While High Dietary Sucrose During Chemotherapy Increases Anxiety-like Behavior in Mice (P14-023-19). Current Developments In Nutrition 2019, 3: nzz052.p14-023-19. PMCID: PMC6573952, DOI: 10.1093/cdn/nzz052.p14-023-19.Peer-Reviewed Original ResearchAnxiety-like behaviorDocosahexaenoic acidIncreases Anxiety-Like BehaviorWeeks of dietBreast cancer patientsAssociation of cytokinesNumber of marblesOvariectomized C57BL/6 miceLess anxiety-like behaviorSignificant differencesSymptoms of anxietyChemotherapy injectionsChemotherapy groupDHA groupHealthy womenFatty acidsMice fedSaline groupC57BL/6 miceInflammatory cytokinesCancer patientsChemotherapy increasesInterleukin-6Results TwentyMouse model