Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy
Ormiston K, Fitzgerald J, Andridge R, Lustberg M, DeVries A, Orchard T. Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy. Nutrition Research 2024, 131: 39-53. PMID: 39368285, DOI: 10.1016/j.nutres.2024.09.004.Peer-Reviewed Original ResearchLiver lipid contentMouse model of chemotherapyLipid contentBody weightLong-term memorySucrose dietLow-sucrose dietDocosahexaenoic acidInsulin resistanceChemotherapy-related cognitive impairmentMouse modelEffects of EPA+DHADoxorubicin-based chemotherapyFemale C57BL/6 miceImpact of chemotherapyAltered insulin resistanceNegatively impacts quality of lifeInsulin resistance scoreDietResistance scoreLower sucrose consumptionEPA+DHARandomized to 1Affective side effectsEicosapentaenoic acid + docosahexaenoic acid