Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice
Ormiston K, Melink Z, Andridge R, Lustberg M, DeVries A, Murphy K, Emmers K, Ziouzenkova O, Belury M, Orchard T. Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice. Brain Behavior And Immunity 2024, 123: 370-382. PMID: 39313165, DOI: 10.1016/j.bbi.2024.09.021.Peer-Reviewed Original ResearchHOMA-IRChemotherapy-related cognitive impairmentHigh-fatDietary eicosapentaenoic acidDocosahexaenoic acidBlood-brain barrier regulationDoxorubicin-based chemotherapyFemale C57BL/6 miceLF groupEicosapentaenoic acidBody fat lossLow-fat (LFHF dietNeuroinflammatory gene expressionLipid metabolismMultiple genesReduction of oxidative stressAlterations of glucoseFat (LFHigh-fat dietGene expressionOvariectomized miceC57BL/6 miceChemotherapy agentsBreast cancer