Genomic risk prediction of aromatase inhibitor‐related arthralgia in patients with breast cancer using a novel machine‐learning algorithm
Reinbolt R, Sonis S, Timmers C, Fernández‐Martínez J, Cernea A, de Andrés‐Galiana E, Hashemi S, Miller K, Pilarski R, Lustberg M. Genomic risk prediction of aromatase inhibitor‐related arthralgia in patients with breast cancer using a novel machine‐learning algorithm. Cancer Medicine 2017, 7: 240-253. PMID: 29168353, PMCID: PMC5773952, DOI: 10.1002/cam4.1256.Peer-Reviewed Original ResearchConceptsAromatase inhibitor-related arthralgiaAromatase inhibitorsBreast cancerSystematic chart reviewBreast cancer patientsTHU0062 Novel animal model of aromatase inhibitor-induced arthralgia suggests an estrogen-independent inflammatory mechanism
Young N, Thomas E, Snoad B, Sharma J, Mobeen M, DeVries A, Bratasz A, Lustberg M, Jarjour W, Reinbolt R. THU0062 Novel animal model of aromatase inhibitor-induced arthralgia suggests an estrogen-independent inflammatory mechanism. Annals Of The Rheumatic Diseases 2017, 76: 222. DOI: 10.1136/annrheumdis-2017-eular.5424.Peer-Reviewed Original ResearchBreast cancer patientsEarly-stage breast cancer patientsAromatase inhibitor-related arthralgiaStage breast cancer patientsBreast cancer researchSerum cytokine levelsBreast cancer survivorsAromatase inhibitorsNovel animal modelInflammatory mechanismsCancer patientsCytokine levelsCancer survivorsMusculoskeletal symptomsRisk factorsHistopathological analysisProspective characterizationAI treatmentHormone receptor-positive breast cancer patientsAnimal modelsReceptor-positive breast cancer patientsNFκB activationAromatase inhibitor-induced arthralgiaBioluminescent imagingKnee jointGenomic risk prediction of aromatase inhibitor-related arthralgias (AIA) in breast cancer (BC) patients using a novel analytical algorithm (NAA).
Reinbolt R, Sonis S, Timmers C, Fernández-Martínez J, deAndrés-Galiana E, Hashemi S, Miller K, Ramaswamy B, Wesolowski R, Noonan A, Dewani S, Williams N, Sardesai S, Pilarski R, Lustberg M. Genomic risk prediction of aromatase inhibitor-related arthralgias (AIA) in breast cancer (BC) patients using a novel analytical algorithm (NAA). Journal Of Clinical Oncology 2017, 35: 10102-10102. DOI: 10.1200/jco.2017.35.15_suppl.10102.Peer-Reviewed Original ResearchAromatase inhibitor-related arthralgiaAromatase inhibitorsSystematic chart reviewBreast cancer patientsCase-control studyPeripheral blood cellsAsymptomatic patientsChart reviewTherapy switchTreatment initiationTreatment complianceBC patientsGenomic risk predictionCancer patientsBreast cancerStage IPatientsClinical phenotypeBlood cellsSNP groupGermline DNACandidate gene studiesStrong association