2023
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance
Yassine I, Rafei R, de la Gandara M, Osman M, Fabre L, Dabboussi F, Hamze M, Weill F. Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance. Microbial Genomics 2023, 9: 001157. PMID: 38100171, PMCID: PMC10763507, DOI: 10.1099/mgen.0.001157.Peer-Reviewed Original ResearchConceptsExtended-spectrum beta-lactamase genesThird-generation cephalosporinsMultidrug resistance phenotypeBeta-lactamase genesAntimicrobial resistance determinantsPrevalent serogroupsClinical isolatesQuinolone resistanceDNA gyrase genesAntimicrobial resistanceResistance determinantsCTXResistance phenotypeAmino acid substitutionsGyrase genesIsolatesNorth LebanonFirst studyAcid substitutionsPoint mutationsGenomic analysisCephalosporins
2021
Species distribution and antifungal susceptibility of Aspergillus clinical isolates in Lebanon
Osman M, Bidon B, Abboud C, Zakaria A, Hamze B, Achcar M, Mallat H, Dannaoui E, Dabboussi F, Papon N, Bouchara J, Hamze M. Species distribution and antifungal susceptibility of Aspergillus clinical isolates in Lebanon. Future Microbiology 2021, 16: 13-26. PMID: 33438473, DOI: 10.2217/fmb-2020-0141.Peer-Reviewed Original ResearchConceptsAntifungal susceptibilityAspergillus clinical isolatesAntifungal susceptibility patternsReverse transcription-quantitative PCRNational Reference CenterOverall drug resistanceTranscription-quantitative PCRInvasive mycosesSusceptibility patternsHealth strategiesEUCAST recommendationsReference centerClinical isolatesAmphotericin BDrug resistanceResistant isolatesMajor causeGene mutationsExpression levelsIsolatesEpidemiologySusceptibilityMycoses
2017
Molecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon
Ashkar S, Osman M, Rafei R, Mallat H, Achkar M, Dabboussi F, Hamze M. Molecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon. Journal Of Infection And Public Health 2017, 10: 745-748. PMID: 28215918, DOI: 10.1016/j.jiph.2016.11.014.Peer-Reviewed Original ResearchConceptsMacrolide resistance genotypesS. pneumoniaeMacrolide resistanceStreptococcus pneumoniaeS. pneumoniae isolatesUse of macrolidesS. pneumoniae strainsNorth LebanonResistance genotypesCMLSB phenotypePolymerase chain reactionPneumoniae isolatesPneumoniae strainsClinical isolatesPneumoniaeChain reactionEfflux pumpsPhenotypic diagnosisCommon resistance genesMolecular detection
2015
Characterization of resistance genes to macrolides, lincosamides and streptogramins (MLS) among clinical isolates of Staphylococcus aureus in North Lebanon
Osman M, Nasbeh A, Rafei R, Mallat H, Achkar M, Dabboussi F, Hamze M. Characterization of resistance genes to macrolides, lincosamides and streptogramins (MLS) among clinical isolates of Staphylococcus aureus in North Lebanon. The International Arabic Journal Of Antimicrobial Agents 2015, 5 DOI: 10.3823/780.Peer-Reviewed Original ResearchClinical isolatesStaphylococcus aureusStaphylococcus aureus infectionS. aureusPrevalence of genesMLS resistance genesMSB phenotypeNini HospitalSignificant morbidityAureus infectionDisc diffusion methodHigh prevalenceLow prevalenceMefA geneNorth LebanonPrevalenceSignificant pathogenL phenotypeResistance determinantsMLS resistanceInducible resistanceAureusErmC genePhenotypeResistance genes