2023
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance
Yassine I, Rafei R, de la Gandara M, Osman M, Fabre L, Dabboussi F, Hamze M, Weill F. Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance. Microbial Genomics 2023, 9: 001157. PMID: 38100171, PMCID: PMC10763507, DOI: 10.1099/mgen.0.001157.Peer-Reviewed Original ResearchConceptsExtended-spectrum beta-lactamase genesThird-generation cephalosporinsMultidrug resistance phenotypeBeta-lactamase genesAntimicrobial resistance determinantsPrevalent serogroupsClinical isolatesQuinolone resistanceDNA gyrase genesAntimicrobial resistanceResistance determinantsCTXResistance phenotypeAmino acid substitutionsGyrase genesIsolatesNorth LebanonFirst studyAcid substitutionsPoint mutationsGenomic analysisCephalosporinsEmergence of Extended-Spectrum Cephalosporin- and Colistin-Resistant Enterobacterales in Otherwise Healthy University Students
Osman M, Yassine I, Hamze M, Al Mir H, Tajani A, Bisha B, Cummings K, Madec J, Haenni M, Kassem I. Emergence of Extended-Spectrum Cephalosporin- and Colistin-Resistant Enterobacterales in Otherwise Healthy University Students. Microbial Drug Resistance 2023, 30: 101-107. PMID: 38011748, DOI: 10.1089/mdr.2023.0213.Peer-Reviewed Original ResearchLast-resort antibioticsHealthy university studentsExtended-spectrum cephalosporin-resistant isolatesComprehensive antimicrobial stewardship programAntimicrobial stewardship programsColistin-resistant isolatesExtended-spectrum cephalosporinsCephalosporin-resistant isolatesColistin-resistant EnterobacteralesMultidrug-resistant bacteriaMiddle-income countriesEvidence-based practiceAntimicrobial stewardshipStewardship programsOccurrence of resistanceCommunity settingsAntimicrobial resistanceClinical samplesAntibiotic resistanceFecal samplesResistance determinantsAntibioticsPublic healthMultiple factorsIsolatesThe emergence of carbapenemase-producing Enterobacterales in hospitals: a major challenge for a debilitated healthcare system in Lebanon
Daaboul D, Oueslati S, Rima M, Kassem I, Mallat H, Birer A, Girlich D, Hamze M, Dabboussi F, Osman M, Naas T. The emergence of carbapenemase-producing Enterobacterales in hospitals: a major challenge for a debilitated healthcare system in Lebanon. Frontiers In Public Health 2023, 11: 1290912. PMID: 38074718, PMCID: PMC10699444, DOI: 10.3389/fpubh.2023.1290912.Peer-Reviewed Original ResearchConceptsKirby-Bauer disk diffusionDifferent Lebanese hospitalsSelf-medication practicesDisk diffusionPublic health systemCarbapenemase-producing EnterobacteralesConventional diagnostic methodsESBL producersHospital settingAntibiotic susceptibilityLebanese hospitalsClinical settingHospitalHealth systemSusceptibility profilesAntimicrobial resistanceHealthcare systemPlasmid typesHealthcare challengesDiagnostic methodsNDMCarbapenemsAMR awarenessIsolatesLebanese communityZoonotic Tuberculosis: A Neglected Disease in the Middle East and North Africa (MENA) Region
Kasir D, Osman N, Awik A, Ratel I, Rafei R, Al Kassaa I, Safadi D, Salma R, Omari K, Cummings K, Kassem I, Osman M. Zoonotic Tuberculosis: A Neglected Disease in the Middle East and North Africa (MENA) Region. Diseases 2023, 11: 39. PMID: 36975589, PMCID: PMC10047434, DOI: 10.3390/diseases11010039.Peer-Reviewed Original ResearchBovine tuberculosisAntimicrobial susceptibility patternsUnpasteurized dairy productsDrug-resistant strainsPrevalence of BTBSerious infectious diseasesPublic health threatAppropriate diagnostic toolsMiddle-income countriesTrue burdenCurrent treatmentSusceptibility patternsPRISMA guidelinesEffective surveillance programEtiologic agentZoonotic tuberculosisMolecular typingPoor hygieneInfectious diseasesDiseaseSurveillance programHealth threatNeglected diseaseAntimicrobial resistanceAvailable studiesAntimicrobial resistance among canine enterococci in the northeastern United States, 2007–2020
Osman M, Altier C, Cazer C. Antimicrobial resistance among canine enterococci in the northeastern United States, 2007–2020. Frontiers In Microbiology 2023, 13: 1025242. PMID: 36687655, PMCID: PMC9849698, DOI: 10.3389/fmicb.2022.1025242.Peer-Reviewed Original ResearchAntimicrobial resistanceCanine populationMultidrug resistanceStudy periodEmpirical antimicrobial treatmentMultivariable logistic regressionAntimicrobial susceptibility patternsRetrospective study designQuality of careMultidrug-resistant bacteriaMinimum inhibitory concentrationEnterococcal infectionsClinical dataSusceptibility patternsPrescribing decisionsClinical enterococciSurveillance studyAntimicrobial treatmentLogistic regressionHealth concernStudy designDiagnostic centersVancomycin resistanceAnimal Health Diagnostic CenterInhibitory concentration
2022
High rates of macrolide and fluoroquinolone resistance in human campylobacteriosis in the Middle East and North Africa
Dabbousi A, Osman M, Dabboussi F, Hamze M. High rates of macrolide and fluoroquinolone resistance in human campylobacteriosis in the Middle East and North Africa. Future Microbiology 2022, 17: 957-967. PMID: 35796073, DOI: 10.2217/fmb-2021-0302.Peer-Reviewed Original ResearchConceptsHuman campylobacteriosisRoutine stool cultureBacterial gastrointestinal infectionsClinical laboratoriesIncidence of campylobacteriosisPaucity of dataMain causative agentStool culturesGastrointestinal infectionsDiarrheal patientsMicrobiological diagnosisClinical importanceFluoroquinolone resistanceInfection prevalenceAntimicrobial resistanceZoonotic diseaseCausative agentCampylobacteriosisHigh rateAlarming ratePatientsCritical needEpidemiologyInfectionPrevalenceThe Emergence and Dissemination of Multidrug Resistant Pseudomonas aeruginosa in Lebanon: Current Status and Challenges during the Economic Crisis
Dabbousi A, Dabboussi F, Hamze M, Osman M, Kassem I. The Emergence and Dissemination of Multidrug Resistant Pseudomonas aeruginosa in Lebanon: Current Status and Challenges during the Economic Crisis. Antibiotics 2022, 11: 687. PMID: 35625331, PMCID: PMC9137902, DOI: 10.3390/antibiotics11050687.Peer-Reviewed Original ResearchMultidrug-resistant Pseudomonas aeruginosaDiabetic foot infectionsChronic airway diseasesLesions of patientsAntimicrobial resistanceHealthcare-associated infectionsResistant Pseudomonas aeruginosaPublic health concernAntimicrobial susceptibility profilesFoot infectionsAirway diseaseNon-clinical settingsMechanical ventilationBurn patientsCommon causeHematological malignanciesAMR surveillance programsCarbapenem resistanceVariety of antimicrobialsHuman infectionsRecalcitrant infectionsSusceptibility profilesSurveillance programHealth concernInfectionGenome sequence of a multidrug-resistant Campylobacter coli strain isolated from a newborn with severe diarrhea in Lebanon
Halimeh F, Rafei R, Diene S, Osman M, Kassem I, Jamal Akoum R, Moudani W, Hamze M, Rolain J. Genome sequence of a multidrug-resistant Campylobacter coli strain isolated from a newborn with severe diarrhea in Lebanon. Folia Microbiologica 2022, 67: 319-328. PMID: 34997523, DOI: 10.1007/s12223-021-00921-w.Peer-Reviewed Original ResearchConceptsCampylobacter coli strainsSevere diarrheaST-828 complexC. coli isolatesBurden of CampylobacterBeta-lactam resistanceNew sequence typesSequencing analysisEpidemiological backgroundColi isolatesWhole-genome sequencing analysisAminoglycoside resistanceC. coliColi strainsAntimicrobial resistanceBlaOXA-61Virulence determinantsDisk diffusionMLST analysisWGS analysisDiarrheaNewbornsPTet plasmidAntimicrobial susceptibility phenotypesSusceptibility phenotype
2018
Epidemiology of antimicrobial resistance in Lebanese extra-hospital settings: An overview
Osman M, Al Mir H, Rafei R, Dabboussi F, Madec J, Haenni M, Hamze M. Epidemiology of antimicrobial resistance in Lebanese extra-hospital settings: An overview. Journal Of Global Antimicrobial Resistance 2018, 17: 123-129. PMID: 30553113, DOI: 10.1016/j.jgar.2018.11.019.Peer-Reviewed Original ResearchConceptsAntimicrobial resistanceExtra-hospital settingsTerms of mortalityMiracle drugAntimicrobial-resistant pathogensNon-clinical settingsSignificant morbidityClinical settingNovel drugsAntimicrobial-resistant bacteriaMultidrug-resistant bacterial strainsSocietal costsInappropriate useCombat infectionEpidemiological situationMorbidityMortalityEpidemiologyDrugsAntibioticsVeterinary medicineAMR crisisMajority of investigationsMolecular mechanisms of antimicrobial resistance in Acinetobacter baumannii, with a special focus on its epidemiology in Lebanon
Jamal S, Al Atrouni A, Rafei R, Dabboussi F, Hamze M, Osman M. Molecular mechanisms of antimicrobial resistance in Acinetobacter baumannii, with a special focus on its epidemiology in Lebanon. Journal Of Global Antimicrobial Resistance 2018, 15: 154-163. PMID: 29859266, DOI: 10.1016/j.jgar.2018.05.022.Peer-Reviewed Original ResearchConceptsAcinetobacter baumanniiA. baumannii outbreaksIntensive care unitAntimicrobial resistanceType of infectionInternational clones ICare unitA. baumanniiHigh mortalityMolecular epidemiologyOpportunistic bacteriumBaumanniiWorldwide emergenceInfectionEpidemiologySpecific clonesMolecular mechanismsClone IMorbidityMolecular techniquesSpecial focusMortalityAvailable data
2017
Molecular mechanisms and epidemiology of resistance in Streptococcus pneumoniae in the Middle East region
El Moujaber G, Osman M, Rafei R, Dabboussi F, Hamze M. Molecular mechanisms and epidemiology of resistance in Streptococcus pneumoniae in the Middle East region. Journal Of Medical Microbiology 2017, 66: 847-858. PMID: 28650313, DOI: 10.1099/jmm.0.000503.Peer-Reviewed Original ResearchConceptsS. pneumoniaeStreptococcus pneumoniaeDrug-resistant S. pneumoniaeAcute otitis mediaNon-invasive infectionsEmergence of multidrugEpidemiology of resistanceS. pneumoniae strainsPrevalence of resistanceMiddle Eastern countriesMolecular mechanismsOtitis mediaMechanisms of resistanceNational surveillanceAntimicrobial stewardshipEastern countriesPneumococcal strainsPneumoniae strainsHigh mortalityNasopharyngeal cavityDecreased susceptibilityCommensal bacteriumSurveillance reportsPneumoniaeAntimicrobial resistance