2020
Endemic Fungi Presenting as Community-Acquired Pneumonia: A Review
Azar MM, Malo J, Hage CA. Endemic Fungi Presenting as Community-Acquired Pneumonia: A Review. Seminars In Respiratory And Critical Care Medicine 2020, 41: 522-537. PMID: 32629490, DOI: 10.1055/s-0040-1702194.Peer-Reviewed Original ResearchMeSH KeywordsBlastomycosisCoccidioidomycosisCommunity-Acquired InfectionsHistoplasmosisHumansLung Diseases, FungalPneumoniaConceptsCommunity-acquired pneumoniaCommon bacterial causeAreas of endemicityDimorphic fungal infectionsRespiratory manifestationsClinical presentationPulmonary histoplasmosisTreatment strategiesDiagnostic modalitiesBacterial causeEndemic areasFungal infectionsPneumoniaHistoplasma capsulatumHistoplasmosisCoccidioides posadasiiBlastomycosisCoccidioidomycosisEpidemiologyDimorphic fungusPresentingReviewPathogenesisInfectionDiagnosisCurrent Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes
Azar MM, Loyd JL, Relich RF, Wheat LJ, Hage CA. Current Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes. Seminars In Respiratory And Critical Care Medicine 2020, 41: 013-030. PMID: 32000281, DOI: 10.1055/s-0039-1698429.Peer-Reviewed Original ResearchMeSH KeywordsAmphotericin BAntifungal AgentsHistoplasmaHistoplasmosisHumansImmunocompromised HostItraconazolePneumoniaRadiographyConceptsDisseminated diseaseCurrent evidence-based approachesProgressive disseminated diseaseCommon clinical presentationCommunity-acquired pneumoniaChronic pulmonary diseaseSelf-limiting diseaseLiposomal amphotericin BManagement of histoplasmosisEvidence-based approachHistoplasmosis syndromeImmunocompetent patientsPulmonary diseaseClinical presentationCrohn's diseasePreferred agentClinical manifestationsCommon conditionMilder casesAmphotericin BHistoplasmosisAmphotericin B.DiseaseEpidemiologyGlobal disease
2018
Central nervous system histoplasmosis
Wheat J, Myint T, Guo Y, Kemmer P, Hage C, Terry C, Azar MM, Riddell J, Ender P, Chen S, Shehab K, Cleveland K, Esguerra E, Johnson J, Wright P, Douglas V, Vergidis P, Ooi W, Baddley J, Bamberger D, Khairy R, Vikram H, Jenny-Avital E, Sivasubramanian G, Bowlware K, Pahud B, Sarria J, Tsai T, Assi M, Mocherla S, Prakash V, Allen D, Passaretti C, Huprikar S, Anderson A. Central nervous system histoplasmosis. Medicine 2018, 97: e0245. PMID: 29595679, PMCID: PMC5895412, DOI: 10.1097/md.0000000000010245.Peer-Reviewed Original ResearchConceptsCentral nervous system histoplasmosisPercent of patientsCerebrospinal fluidAmphotericin BCentral nervous system involvementSingle-center case seriesNervous system involvementLiposomal amphotericin BCenter case seriesOutcome of treatmentAnti-Histoplasma antibodiesRecognition of infectionPatients 54 yearsCNS histoplasmosisDeoxycholate formulationDisseminated histoplasmosisMost patientsAntigen testingAntibody testingCase seriesImmunodeficiency syndromeHistoplasma antigenHistoplasmosis infectionSystem involvementYear survival
2017
Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States
Azar MM, Zhang X, Assi R, Hage C, Wheat LJ, Malinis MF. Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States. Medical Mycology 2017, 56: 896-899. PMID: 29228334, DOI: 10.1093/mmy/myx120.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHistoplasmosis casesEpidemiology of histoplasmosisNon-endemic areasSymptom onsetAntigen testingMedian timeImmunodeficiency virusActive histoplasmosisNonendemic areasRetrospective analysisEndemic areasEpidemiological characterizationHistoplasmosisNew HavenDaysPatientsEpidemiologyDiagnosisCasesClinical Perspectives in the Diagnosis and Management of Histoplasmosis
Azar MM, Hage CA. Clinical Perspectives in the Diagnosis and Management of Histoplasmosis. Clinics In Chest Medicine 2017, 38: 403-415. PMID: 28797485, DOI: 10.1016/j.ccm.2017.04.004.BooksConceptsAcute pulmonary histoplasmosisDrug of choiceManagement of histoplasmosisDisseminated presentationPulmonary histoplasmosisMild diseaseClinical spectrumDimorphic fungus Histoplasma capsulatumHistoplasmosisAmphotericin BFungus Histoplasma capsulatumClinical perspectiveDiseaseHistoplasma capsulatumMultipronged approachNumber of travelersDiagnosisPatientsTherapyItraconazoleSeverityLaboratory Diagnostics for Histoplasmosis
Azar MM, Hage CA. Laboratory Diagnostics for Histoplasmosis. Journal Of Clinical Microbiology 2017, 55: 1612-1620. PMID: 28275076, PMCID: PMC5442517, DOI: 10.1128/jcm.02430-16.Books
2016
Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines.
Azar MM, Malinis MF. Disseminated Histoplasmosis with Skin Lesions and Osteomyelitis in a Patient from the Philippines. American Journal Of Tropical Medicine And Hygiene 2016, 95: 70-4. PMID: 26976880, PMCID: PMC4944712, DOI: 10.4269/ajtmh.16-0063.Peer-Reviewed Case Reports and Technical NotesConceptsBone involvementDisseminated histoplasmosisFoot woundsPapular rashProtean manifestationsFinal diagnosisUnusual manifestationSkin lesionsDimorphic fungus Histoplasma capsulatumHistoplasmosisFungus Histoplasma capsulatumHistoplasma capsulatumDiseaseManifestationsRashOsteomyelitisPatientsLesionsDiagnosisHistoplasmosis
Wheat LJ, Azar MM, Bahr NC, Spec A, Relich RF, Hage C. Histoplasmosis. Infectious Disease Clinics Of North America 2016, 30: 207-227. PMID: 26897068, DOI: 10.1016/j.idc.2015.10.009.Books
2015
Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management
Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ. Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management. Seminars In Respiratory And Critical Care Medicine 2015, 36: 729-745. PMID: 26398539, DOI: 10.1055/s-0035-1562899.BooksConceptsMost patientsPulmonary diseaseAcute pulmonary diseaseChronic cavitary pneumoniaCommon endemic mycosisProgressive disseminated diseaseCommon clinical presentationCommunity-acquired pneumoniaChronic pulmonary diseaseEvaluation of patientsLiposomal amphotericin BDate evidence-based approachGranulomatous inflammatory diseaseDiagnosis of histoplasmosisEvidence-based approachMediastinal manifestationsCavitary pneumoniaDisseminated diseaseClinical presentationCrohn's diseasePreferred agentClinical syndromeAnaerobic infectionsInflammatory diseasesEndemic mycosis