2019
Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis
Yun S, Hu R, Schwaemmle ME, Scherer AN, Zhuang Z, Koleske AJ, Pallas DC, Schwartz MA. Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis. Journal Of Clinical Investigation 2019, 129: 4863-4874. PMID: 31408443, PMCID: PMC6819111, DOI: 10.1172/jci127692.Peer-Reviewed Original ResearchConceptsPP2A regulatory subunit B55αTranscription factor YAPActive PDEComplex assemblyAdapter rolePDE4D5B55αIntegrin α5EC phenotypeCell functionInflammatory signalingAthero-prone regionsActivationComplexesPP2AInflammatory activationWidespread consequencesDephosphorylationProteomicsVascular remodelingPlaque sizeAtherosclerotic plaque sizeSignalingYAPRegulates
2011
Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling
Norambuena A, Schwartz MA. Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling. Molecular Biology Of The Cell 2011, 22: 3456-3464. PMID: 21795400, PMCID: PMC3172269, DOI: 10.1091/mbc.e11-04-0361.Peer-Reviewed Original ResearchConceptsLipid raft componentsRaft componentsLipid raftsCyclic adenosine monophosphateCell detachmentCell adhesionLipid raft markersGlycosylphosphatidylinositol-linked proteinsRaft associationRaft markersRho GTPasesNonraft fractionsDetachment of cellsElevation of cAMPStudy of integrinsTermination of growthPlasma membraneH-RasAnchorage dependenceKey defenseCell growthFlotillin2Sucrose gradientsCancer metastasisLipid tails
2000
Antibody-Induced Activation of β1 Integrin Receptors Stimulates cAMP-Dependent Migration of Breast Cells on Laminin-5
Plopper G, Huff J, Rust W, Schwartz M, Quaranta V. Antibody-Induced Activation of β1 Integrin Receptors Stimulates cAMP-Dependent Migration of Breast Cells on Laminin-5. Archives Of Biochemistry And Biophysics 2000, 4: 129-135. PMID: 11170844, DOI: 10.1006/mcbr.2001.0267.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine Diphosphate RiboseAntibodies, MonoclonalBreast NeoplasmsCell AdhesionCell Adhesion MoleculesCell MovementCells, CulturedCyclic AMPDNA PrimersFemaleHeterotrimeric GTP-Binding ProteinsHumansIntegrin alpha3beta1IntegrinsPertussis ToxinPrecipitin TestsReceptors, LamininSignal TransductionTumor Cells, CulturedVirulence Factors, Bordetella
1997
Role of Rho and myosin phosphorylation in actin stress fiber assembly in mesangial cells
Kreisberg J, Ghosh-Choudhury N, Radnik R, Schwartz M. Role of Rho and myosin phosphorylation in actin stress fiber assembly in mesangial cells. American Journal Of Physiology 1997, 273: f283-f288. PMID: 9277589, DOI: 10.1152/ajprenal.1997.273.2.f283.Peer-Reviewed Original Research