2019
Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis
Yun S, Hu R, Schwaemmle ME, Scherer AN, Zhuang Z, Koleske AJ, Pallas DC, Schwartz MA. Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis. Journal Of Clinical Investigation 2019, 129: 4863-4874. PMID: 31408443, PMCID: PMC6819111, DOI: 10.1172/jci127692.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 4Integrin alpha5beta1MiceMice, Mutant StrainsProtein Phosphatase 2Second Messenger SystemsConceptsPP2A regulatory subunit B55αTranscription factor YAPActive PDEComplex assemblyAdapter rolePDE4D5B55αIntegrin α5EC phenotypeCell functionInflammatory signalingAthero-prone regionsActivationComplexesPP2AInflammatory activationWidespread consequencesDephosphorylationProteomicsVascular remodelingPlaque sizeAtherosclerotic plaque sizeSignalingYAPRegulates
1996
The Regulation of Growth and Intracellular Signaling by Integrins
Meredith J, Winitz S, Lewis J, Hess S, Ren X, Renshaw M, Schwartz M. The Regulation of Growth and Intracellular Signaling by Integrins. Endocrine Reviews 1996, 17: 207-220. PMID: 8771356, DOI: 10.1210/edrv-17-3-207.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCell SurvivalCytoskeletonGene ExpressionHumansIntegrinsProtein KinasesSecond Messenger SystemsSignal TransductionConceptsReceptor cytoplasmic domainIntegrin-ligand bindingShort cytoplasmic regionLarge extracellular domainRegulation of growthExtracellular matrix proteinsCell surface receptorsDomain bindsCytoplasmic domainDifferent α subunitsTransmembrane regionTransmembrane receptorsCytoplasmic regionCytoskeletal proteinsKinase activationGene expressionΑ-subunitDifferent β subunitsExtracellular domainIntracellular signalingΒ-subunitAdhesion receptorsMatrix proteinsCell migrationCell growth