2001
Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration
Calderwood D, Huttenlocher A, Kiosses W, Rose D, Woodside D, Schwartz M, Ginsberg M. Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration. Nature Cell Biology 2001, 3: 1060-1068. PMID: 11781567, DOI: 10.1038/ncb1201-1060.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBinding SitesCell MovementCell PolarityCHO CellsContractile ProteinsCricetinaeCytoplasmCytoskeletonFibronectinsFilaminsFocal AdhesionsHumansIntegrin beta ChainsIntegrinsIsoleucineJurkat CellsMicrofilament ProteinsProtein Structure, TertiaryRecombinant Fusion ProteinsTalinValineConceptsFocal adhesion formationFilamin bindingCell migrationMembrane protrusionsMatrix assemblyIntegrin-dependent cell migrationFibronectin matrix assemblyAmino acid substitutionsInhibits cell migrationAnimal developmentActin cytoskeletonIntegrin tailsBiochemical signalsAdhesion receptorsFilaminCell polarizationTalinAcid substitutionsExtracellular matrixAdhesion formationTailBindingAssemblyMigrationSelective loss
1995
Integrins: Emerging Paradigms of Signal Transduction
Schwartz M, Schaller M, Ginsberg M. Integrins: Emerging Paradigms of Signal Transduction. Annual Review Of Cell And Developmental Biology 1995, 11: 549-599. PMID: 8689569, DOI: 10.1146/annurev.cb.11.110195.003001.Peer-Reviewed Original Research
1988
How actin binds and assembles onto plasma membranes from Dictyostelium discoideum.
Schwartz M, Luna E. How actin binds and assembles onto plasma membranes from Dictyostelium discoideum. Journal Of Cell Biology 1988, 107: 201-209. PMID: 3392099, PMCID: PMC2115166, DOI: 10.1083/jcb.107.1.201.Peer-Reviewed Original ResearchConceptsPolymerizationSuccessive monomersMembrane surfacePositive cooperativityActin trimerTight bindingAssembly stateHistidine-40Critical concentrationLow salt bufferDerivativesSalt bufferEthoxyformic anhydrideCooperativitySolutionMonomersMembraneAffinityMultivalencyOligomersAnhydrideActin nucleiBindingCross-linking experimentsActin oligomers