2018
Talin as a mechanosensitive signaling hub
Goult BT, Yan J, Schwartz MA. Talin as a mechanosensitive signaling hub. Journal Of Cell Biology 2018, 217: 3776-3784. PMID: 30254032, PMCID: PMC6219721, DOI: 10.1083/jcb.201808061.Peer-Reviewed Original ResearchConceptsSignaling hubsExtracellular matrixRod domainTalin rod domainIntegrin β subunitsDifferent protein interactionsLong rod domainSwitch-like behaviorActin cytoskeletonCytoplasmic domainCytoplasmic proteinsProtein interactionsHelical bundleGlobular head domainTalin functionTransmembrane receptorsHelix bundleΒ-subunitHead domainIntegrin familyTalinCell adhesionIndividual domainsRecent evidenceDomain
1996
The Regulation of Growth and Intracellular Signaling by Integrins
Meredith J, Winitz S, Lewis J, Hess S, Ren X, Renshaw M, Schwartz M. The Regulation of Growth and Intracellular Signaling by Integrins. Endocrine Reviews 1996, 17: 207-220. PMID: 8771356, DOI: 10.1210/edrv-17-3-207.Peer-Reviewed Original ResearchConceptsReceptor cytoplasmic domainIntegrin-ligand bindingShort cytoplasmic regionLarge extracellular domainRegulation of growthExtracellular matrix proteinsCell surface receptorsDomain bindsCytoplasmic domainDifferent α subunitsTransmembrane regionTransmembrane receptorsCytoplasmic regionCytoskeletal proteinsKinase activationGene expressionΑ-subunitDifferent β subunitsExtracellular domainIntracellular signalingΒ-subunitAdhesion receptorsMatrix proteinsCell migrationCell growth