2017
Endothelial Notch signalling limits angiogenesis via control of artery formation
Hasan SS, Tsaryk R, Lange M, Wisniewski L, Moore JC, Lawson ND, Wojciechowska K, Schnittler H, Siekmann AF. Endothelial Notch signalling limits angiogenesis via control of artery formation. Nature Cell Biology 2017, 19: 928-940. PMID: 28714969, PMCID: PMC5534340, DOI: 10.1038/ncb3574.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArteriesCell MovementCells, CulturedEndothelial CellsGene Expression Regulation, DevelopmentalGenotypeHomeodomain ProteinsHuman Umbilical Vein Endothelial CellsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMicroscopy, FluorescenceMicroscopy, VideoNeovascularization, PhysiologicNerve Tissue ProteinsPhenotypeReceptor, Notch1Receptors, CXCR4Signal TransductionTime FactorsTime-Lapse ImagingTransfectionZebrafishZebrafish ProteinsConceptsNotch signalingTip cellsBlood vessel growthChemokine receptor cxcr4aTip cell migrationArtery formationNotch ligand DLL4Role of NotchVessel growthStalk cellsNotch activationAngiogenic sproutingLigand DLL4Endothelial NotchCell migrationSignalingPlexus formationBlood flow patternsAngiogenesisArterial circulationCellsNotchExpressionCxcr4aZebrafish
2014
A new paradigm for transcription factor TFIIB functionality
Gelev V, Zabolotny JM, Lange M, Hiromura M, Yoo SW, Orlando JS, Kushnir A, Horikoshi N, Paquet E, Bachvarov D, Schaffer PA, Usheva A. A new paradigm for transcription factor TFIIB functionality. Scientific Reports 2014, 4: 3664. PMID: 24441171, PMCID: PMC3895905, DOI: 10.1038/srep03664.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnimalsBinding SitesCell CycleCell LineDatasets as TopicGene ExpressionGene Expression ProfilingGene Expression RegulationGene Expression Regulation, ViralGene Knockdown TechniquesGene SilencingGenes, LethalGenome, HumanHerpesvirus 1, HumanHumansOrgan SpecificityProtein BindingRNA Polymerase IITranscription Factor TFIIBTranscription Initiation SiteTranscription, GeneticTranscriptomeConceptsTranscription initiationGene expressionGeneral transcription factor TFIIBTranscription factor TFIIBRNA polymerase IIGlobal gene expressionHuman gene expressionPolymerase IIGene transcriptionBioinformatics analysisBioinformatics studiesGene promoterHuman promotersCellular functionalityMitotic chromatidsTFIIBCell linesTranscriptionPromoterExpression