Martin Lange
Associate Research ScientistCards
About
Research
Publications
2024
Exosomes: A New Hope for Angiogenesis-Mediated Bone Regeneration.
Lange M, Babczyk P, Tobiasch E. Exosomes: A New Hope for Angiogenesis-Mediated Bone Regeneration. Int J Mol Sci 2024, 25 PMID: 38791243, DOI: 10.3390/ijms25105204.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2023
Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption
Zarkada G, Chen X, Zhou X, Lange M, Zeng L, Lv W, Zhang X, Li Y, Zhou W, Liu K, Chen D, Ricard N, Liao J, Kim Y, Benedito R, Claesson-Welsh L, Alitalo K, Simons M, Ju R, Li X, Eichmann A, Zhang F. Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption. Circulation Research 2023, 133: 333-349. PMID: 37462027, PMCID: PMC10530007, DOI: 10.1161/circresaha.123.322607.Peer-Reviewed Original ResearchConceptsLymphatic endothelial cellsCell-cell junctionsCytoskeleton contractionMolecular biology approachesSmall GTPase Rac1Cytoskeletal contractilityBiology approachGTPase Rac1Stress fibersA SignalingPI3KLipid uptakePermeability regulationLymphatic permeabilityIntestinal lipid absorptionLEC junctionJunction openingEndothelial cellsLymphatic capillariesVEGFR-2Fundamental mechanismsLymphatic barrierLymphatic vesselsVascular endothelial growthLymphatic junctions
2022
Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling
Lange M, Ohnesorge N, Hoffmann D, Rocha SF, Benedito R, Siekmann AF. Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling. Developmental Biology 2022, 486: 26-43. PMID: 35337795, PMCID: PMC11238767, DOI: 10.1016/j.ydbio.2022.03.006.Peer-Reviewed Original ResearchConceptsEndothelial cell migrationLong isoformPI3KCell migrationEC proliferationZebrafish trunkZebrafish mutantsMutant phenotypeCellular functionsIntersegmental blood vesselsMRNA splicingPI3-kinaseMAPK activationVegfabA PathwayERK phosphorylationExtracellular matrixEndothelial cell proliferationVEGFA isoformsIsoformsCell proliferationDistinct setsProliferationBlood vessel networkMutations
2017
Endothelial Notch signalling limits angiogenesis via control of artery formation
Hasan SS, Tsaryk R, Lange M, Wisniewski L, Moore JC, Lawson ND, Wojciechowska K, Schnittler H, Siekmann AF. Endothelial Notch signalling limits angiogenesis via control of artery formation. Nature Cell Biology 2017, 19: 928-940. PMID: 28714969, PMCID: PMC5534340, DOI: 10.1038/ncb3574.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArteriesCell MovementCells, CulturedEndothelial CellsGene Expression Regulation, DevelopmentalGenotypeHomeodomain ProteinsHuman Umbilical Vein Endothelial CellsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMicroscopy, FluorescenceMicroscopy, VideoNeovascularization, PhysiologicNerve Tissue ProteinsPhenotypeReceptor, Notch1Receptors, CXCR4Signal TransductionTime FactorsTime-Lapse ImagingTransfectionZebrafishZebrafish ProteinsConceptsNotch signalingTip cellsBlood vessel growthChemokine receptor cxcr4aTip cell migrationArtery formationNotch ligand DLL4Role of NotchVessel growthStalk cellsNotch activationAngiogenic sproutingLigand DLL4Endothelial NotchCell migrationSignalingPlexus formationBlood flow patternsAngiogenesisArterial circulationCellsNotchExpressionCxcr4aZebrafishReprimo tissue-specific expression pattern is conserved between zebrafish and human
Figueroa RJ, Carrasco-Avino G, Wichmann IA, Lange M, Owen GI, Siekmann AF, Corvalán AH, Opazo JC, Amigo JD. Reprimo tissue-specific expression pattern is conserved between zebrafish and human. PLOS ONE 2017, 12: e0178274. PMID: 28562620, PMCID: PMC5451059, DOI: 10.1371/journal.pone.0178274.Peer-Reviewed Original ResearchConceptsTissue-specific expression patternsExpression patternsGene familyExpression profilesSpatiotemporal expression profilesSitu hybridizationP53-mediated cell cycle arrestG2/M.Tumor suppressor geneUnique expression profileCell cycle arrestZebrafish developmentPhylogenetic analysisMost speciesMalignant tumor progressionGene transcriptsZebrafishProtein productsSpatiotemporal expressionCycle arrestReprimoCentral nervous systemPathological roleModel systemRT-qPCR
2015
Lysophosphatidic acid generation by pulmonary NKT cell ENPP-2/autotaxin exacerbates hyperoxic lung injury
Nowak-Machen M, Lange M, Exley M, Wu S, Usheva A, Robson SC. Lysophosphatidic acid generation by pulmonary NKT cell ENPP-2/autotaxin exacerbates hyperoxic lung injury. Purinergic Signalling 2015, 11: 455-461. PMID: 26306905, PMCID: PMC4648788, DOI: 10.1007/s11302-015-9463-6.Peer-Reviewed Original ResearchConceptsPulmonary NKT cellsHyperoxic lung injuryNKT cellsLung injuryBrP-LPALysophosphatidic acidLPA levelsNKT cell numbersNKT cell activationCell numberLPA antagonistsLPA generationIll patientsSerum levelsOrgan oxygenationMouse modelClinical practiceCell activationInjuryEctonucleotide pyrophosphatase/phosphodiesterase 2HyperoxiaToxic effectsVivoPhosphodiesterase 2Autotaxin
2014
A new paradigm for transcription factor TFIIB functionality
Gelev V, Zabolotny JM, Lange M, Hiromura M, Yoo SW, Orlando JS, Kushnir A, Horikoshi N, Paquet E, Bachvarov D, Schaffer PA, Usheva A. A new paradigm for transcription factor TFIIB functionality. Scientific Reports 2014, 4: 3664. PMID: 24441171, PMCID: PMC3895905, DOI: 10.1038/srep03664.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnimalsBinding SitesCell CycleCell LineDatasets as TopicGene ExpressionGene Expression ProfilingGene Expression RegulationGene Expression Regulation, ViralGene Knockdown TechniquesGene SilencingGenes, LethalGenome, HumanHerpesvirus 1, HumanHumansOrgan SpecificityProtein BindingRNA Polymerase IITranscription Factor TFIIBTranscription Initiation SiteTranscription, GeneticTranscriptomeConceptsTranscription initiationGene expressionGeneral transcription factor TFIIBTranscription factor TFIIBRNA polymerase IIGlobal gene expressionHuman gene expressionPolymerase IIGene transcriptionBioinformatics analysisBioinformatics studiesGene promoterHuman promotersCellular functionalityMitotic chromatidsTFIIBCell linesTranscriptionPromoterExpression
2013
Arterial territory-specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens
Lange M, Fujikawa T, Koulova A, Kang S, Griffin M, Lassaletta A, Erat A, Tobiash E, Bianchi C, Elmadhun N, Sellke F, Usheva A. Arterial territory-specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens. Cell Cycle 2013, 13: 315-323. PMID: 24240190, PMCID: PMC3906247, DOI: 10.4161/cc.27056.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCell ProliferationCoronary VesselsCulture Media, Serum-FreeCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase Inhibitor p15Gene Knockdown TechniquesHumansMaleMammary ArteriesMitogensMyocytes, Smooth MusclePhosphorylationPrimary Cell CultureRetinoblastoma ProteinSerumSwineYY1 Transcription FactorConceptsCyclin-dependent kinase 2Internal mammary arteryCoronary artery SMCsDisease resistanceRb phosphorylationRetinoblastoma tumor suppressor proteinTumor suppressor proteinMammary arteryCoronary arteryCultured human cellsVascular smooth muscle cell responsesProtein speciesPhosphorylation profileSmooth muscle cell dedifferentiationSuppressor proteinPrevalence of restenosisKinase 2Serum stimulationMolecular mechanismsSmooth muscle cell responseMuscle cell dedifferentiationHuman cellsSMC populationCause of mortalitySiRNA knockdown
2012
DNA breathing dynamics distinguish binding from nonbinding consensus sites for transcription factor YY1 in cells
Alexandrov BS, Fukuyo Y, Lange M, Horikoshi N, Gelev V, Rasmussen KØ, Bishop AR, Usheva A. DNA breathing dynamics distinguish binding from nonbinding consensus sites for transcription factor YY1 in cells. Nucleic Acids Research 2012, 40: 10116-10123. PMID: 22904068, PMCID: PMC3488223, DOI: 10.1093/nar/gks758.Peer-Reviewed Original ResearchConceptsTranscription factorsGenome-wide mappingProtein-DNA bindingGene expression regulatorsEssential biological processesTranscription factor YY1DNA binding sitesDNA breathing dynamicsGenomic functionsYY1 bindingFactor YY1Expression regulatorsPhenotypic diversityConsensus sitesSequence variationGel shiftBiological processesCellular behaviorSequence contextFunctional SNPsYY1Strand separationBreathing dynamicsDNA dynamicsBinding sitesRecent Patents on Biomedical Applications for the Treatment of Atherosclerosis
Limbach CA, Lange M, Schulze M, Tobiasch E. Recent Patents on Biomedical Applications for the Treatment of Atherosclerosis. Recent Patents on Regenerative Medicine. 2012 April; 2(2):75 - 102. doi: 10.2174/2210296511202020075.Books