Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors
Boulianne B, Robinson ME, May PC, Castellano L, Blighe K, Thomas J, Reid A, Müschen M, Apperley JF, Stebbing J, Feldhahn N. Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors. Cell Reports 2017, 18: 1687-1698. PMID: 28199841, PMCID: PMC5318656, DOI: 10.1016/j.celrep.2017.01.057.Peer-Reviewed Original ResearchConceptsLineage-specific genesDNA damageDe novo DNA damageB cell precursorsB lineage-specific genesPrimary B-cell precursorHuman leukemiaB lineage genesLineage-specific alterationsMyeloid-specific genesCell precursorsGlobal DNA damageLymphoid-specific genesGene bodiesLineage genesChIP-seqDamage hotspotsGenomic lesionsLineage phenotypeGenesProminent targetIdentified regionsDeletionFrequent alterationsPredominant target