2015
Drug-Induced Glomerular Disease: Direct Cellular Injury
Markowitz GS, Bomback AS, Perazella MA. Drug-Induced Glomerular Disease: Direct Cellular Injury. Clinical Journal Of The American Society Of Nephrology 2015, 10: 1291-1299. PMID: 25862776, PMCID: PMC4491280, DOI: 10.2215/cjn.00860115.Peer-Reviewed Original ResearchConceptsGlomerular diseaseCell injuryGlomerular lesionsNonsteroidal anti-inflammatory drugsAcute interstitial nephritisDrug-induced etiologyPotential of medicationsRenal function recoveryAcute tubular necrosisEndothelial cell injuryMesangial cell injuryEpithelial cell injuryAnti-inflammatory drugsDirect cellular injuryRapid discontinuationKidney injuryTubular necrosisAntiplatelet agentsInterstitial nephritisTubulointerstitial compartmentFunction recoveryIatrogenic formCellular injuryAntiangiogenesis drugsInjury
1997
Hypertension and hypokalemia: unusual syndromes.
Cruz D, Perazella M. Hypertension and hypokalemia: unusual syndromes. Connecticut Medicine 1997, 61: 67-75. PMID: 9066195.Peer-Reviewed Original ResearchConceptsSecondary hypertensionMedical historyApparent mineralocorticoid excess syndromeAdrenal enzyme defectsAssociation of hypertensionHigh-renin statesLow renin stateMineralocorticoid excess stateMineralocorticoid excess syndromeCases of hypertensionRenal potassium wastingPatient's medical historyPrimary hyperaldosteronismRenovascular diseasePotassium wastingLaboratory parametersLicorice ingestionClinical presentationMineralocorticoid excessClinical syndromeRare patientsPathogenetic mechanismsExcess syndromeUnusual syndromeHypertension
1996
Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose.
Perazella M, Mahnensmith R. Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose. Clinical Nephrology 1996, 46: 187-92. PMID: 8879854.Peer-Reviewed Original ResearchConceptsTrimethoprim-sulfamethoxazole therapyStandard doseDevelopment of hyperkalemiaTrimethoprim-sulfamethoxazole useMild renal insufficiencyProspective surveillance studyPotassium-sparing diuretic amilorideRenal potassium excretionPneumocystis carinii pneumoniaLethal adverse reactionHandful of casesRenal insufficiencyElderly patientsPotassium excretionSevere hyperkalemiaImportant complicationAIDS patientsCarinii pneumoniaTrimethoprim-sulfamethoxazoleAdverse reactionsInduced hyperkalemiaPotassium disordersHyperkalemiaSurveillance studyPatients
1994
Acute Nonspecific Illness in an AIDS Patient with Dysphagia
Perazella M, Sadigh M. Acute Nonspecific Illness in an AIDS Patient with Dysphagia. Hospital Practice 1994, 29: 39-47. PMID: 7962235, DOI: 10.1080/21548331.1994.11443104.Peer-Reviewed Original Research