2023
Acquired Disorders of Hypomagnesemia
Rosner M, Ha N, Palmer B, Perazella M. Acquired Disorders of Hypomagnesemia. Mayo Clinic Proceedings 2023, 98: 581-596. PMID: 36872194, DOI: 10.1016/j.mayocp.2022.12.002.Peer-Reviewed Original ResearchConceptsReduced glomerular filtration rateBody storesBody magnesium storesGlomerular filtration rateSerum magnesium levelsTotal body storesDevelopment of symptomsIntravenous replacementOrgan dysfunctionMagnesium disordersRenal lossMagnesium replacementFiltration rateSevere casesMagnesium storesHypomagnesemiaClinical experienceClinical practiceMagnesium levelsAcquired disordersAmphotericin BMagnesium handlingOptimal managementMedicationsLaboratory assessment
2022
Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury
Sprangers B, Leaf DE, Porta C, Soler MJ, Perazella MA. Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury. Nature Reviews Nephrology 2022, 18: 794-805. PMID: 36168055, DOI: 10.1038/s41581-022-00630-8.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsAcute kidney injuryKidney injuryKidney biopsyAcute tubulo-interstitial nephritisImmune-related adverse eventsConcomitant anticancer therapyTubulo-interstitial nephritisEffector T cellsEvaluation of patientsLoss of toleranceCheckpoint inhibitorsPartial remissionPermanent discontinuationAdverse eventsMost patientsAppropriate treatmentEarly initiationT cellsClinical practiceFavorable responsePatientsAccurate diagnosisCancer treatmentAnticancer therapy
2021
Immunotherapy-Related Acute Kidney Injury
Manohar S, Jhaveri KD, Perazella MA. Immunotherapy-Related Acute Kidney Injury. Advances In Kidney Disease And Health 2021, 28: 429-437.e1. PMID: 35190109, DOI: 10.1053/j.ackd.2021.07.006.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor T-cell therapyEffective immune checkpoint inhibitorsAcute kidney injuryImmune checkpoint inhibitorsHigh-dose interleukinNumerous clinical trialsT-cell therapyField of oncologyCheckpoint inhibitorsKidney injuryGeneration immunotherapiesClinical trialsClinical practiceImmunotherapyImmune systemAdverse effectsNephrotoxicityInterleukinPathophysiologyInjuryTherapyCancerOncologyTrialsCheckpoint inhibitor therapy-associated acute kidney injury: time to move on to evidence-based recommendations
Perazella MA, Sprangers B. Checkpoint inhibitor therapy-associated acute kidney injury: time to move on to evidence-based recommendations. Clinical Kidney Journal 2021, 14: 1301-1306. PMID: 33970161, PMCID: PMC8087122, DOI: 10.1093/ckj/sfab052.Peer-Reviewed Original ResearchAcute kidney injuryImmune checkpoint inhibitorsAcute tubulointerstitial nephritisKidney biopsyImmune-related adverse eventsVall d'Hebron University HospitalSingle-center studyNoninvasive diagnostic markerEvidence-based recommendationsAKI patientsICI rechallengeNephrology servicesCheckpoint inhibitorsICI treatmentKidney injuryAdverse eventsTubulointerstitial nephritisNonhematologic malignanciesUniversity HospitalTreatment protocolClinical practicePatientsOptimal managementDiagnostic markerCancer treatment
2020
The kidney–cancer connection continues to grow
Perazella M. The kidney–cancer connection continues to grow. Journal Of Onco-Nephrology 2020, 4: 26-27. DOI: 10.1177/2399369320916474.Peer-Reviewed Original Research
2019
Evolution of the kidney–cancer connection
Perazella M, Workeneh B, Chen S. Evolution of the kidney–cancer connection. Journal Of Onco-Nephrology 2019, 3: 88-91. DOI: 10.1177/2399369319841616.Peer-Reviewed Original ResearchOnco-NephrologyKidney diseaseCare medicineMD Anderson Cancer CenterPalliative care medicineAnderson Cancer CenterCritical care medicineCancer CenterClinical pharmacologyClinical practiceAreas of medicineCancerDiseaseSpecialty groupsPatientsClinical medicineHighlights sectionMedicineTherapyNephrologyOncologyHematologyUrologyPharmacology
2015
The Urine Sediment as a Biomarker of Kidney Disease
Perazella MA. The Urine Sediment as a Biomarker of Kidney Disease. American Journal Of Kidney Diseases 2015, 66: 748-755. PMID: 25943719, DOI: 10.1053/j.ajkd.2015.02.342.Peer-Reviewed Original ResearchConceptsUrine sediment examinationKidney diseaseSediment examinationKidney conditionsUrine sedimentNovel urine biomarkersNew candidate biomarkersCentralized laboratory testingKidney injuryUrine biomarkersNew diagnostic technologiesUrinary biomarkersClinical practiceCandidate biomarkersTime-honored testsMaintenance of competencyDiagnostic panelDiagnostic testsDiseaseBiomarkersCliniciansUseful batteryExaminationDiagnostic informationDiagnostic technologies