2023
Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus
Yang M, Lam T, Kanyo J, Kang I, Zhou Z, Clarke S, Mamula M. Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus. Autoimmunity 2023, 56: 2282945. PMID: 37994408, PMCID: PMC10897934, DOI: 10.1080/08916934.2023.2282945.Peer-Reviewed Original Research
2022
Biomarkers of autoimmunity and beta cell metabolism in type 1 diabetes
Yang M, Kibbey R, Mamula M. Biomarkers of autoimmunity and beta cell metabolism in type 1 diabetes. Frontiers In Immunology 2022, 13: 1028130. PMID: 36389721, PMCID: PMC9647083, DOI: 10.3389/fimmu.2022.1028130.Peer-Reviewed Original ResearchMeSH KeywordsAutoimmune DiseasesAutoimmunityBiomarkersDiabetes Mellitus, Type 1HumansInsulin-Secreting CellsConceptsPosttranslational protein modificationMetabolic pathwaysType 1 diabetesCellular metabolic pathwaysImportant biological functionsAutoimmune diseasesBeta cellsCellular metabolic dysfunctionPancreatic isletsProtein modificationBiological functionsProtein structureInsulin-producing beta cellsBiomarkers of autoimmunityChronic autoimmune diseaseCell metabolismBeta-cell metabolismNumerous autoimmune diseasesPancreatic beta cellsPotential pathological consequencesNormal metabolic pathwaysDisease activityPathological consequencesSpecific autoantigensSpecific autoimmunity
2001
Post-translational protein modifications in antigen recognition and autoimmunity
Doyle H, Mamula M. Post-translational protein modifications in antigen recognition and autoimmunity. Trends In Immunology 2001, 22: 443-449. PMID: 11473834, DOI: 10.1016/s1471-4906(01)01976-7.Peer-Reviewed Original Research
2000
Molecular mimicry and the role of B lymphocytes in the processing of autoantigens
Liang B, Mamula* M. Molecular mimicry and the role of B lymphocytes in the processing of autoantigens. Cellular And Molecular Life Sciences 2000, 57: 561-568. PMID: 11130456, PMCID: PMC11147036, DOI: 10.1007/pl00000718.Peer-Reviewed Original ResearchConceptsSelf proteinsB lymphocytesAutoimmune T cell responsesT cell responsesT lymphocyte repertoireAutoreactive cellsSelf antigensAutoimmune diseasesElicit autoimmunityT lymphocytesSelf toleranceSelf peptidesImmune systemMolecular mimicryCell responsesLymphocyte repertoireLymphocytesNormal inhabitantPathogenic agentsInappropriate levelsForeign peptidesMolecular mimicsAutoimmunityAutoantigens
1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityB-LymphocytesBinding, CompetitiveCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponse
1998
Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes
Mamula M, Mamula M. Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes. Immunological Reviews 1998, 164: 231-233. PMID: 9795779, DOI: 10.1111/j.1600-065x.1998.tb01223.x.Peer-Reviewed Original ResearchMeSH KeywordsAntigen PresentationAutoantigensAutoimmunityB-LymphocytesEpitopesLupus Erythematosus, SystemicMolecular MimicryConceptsImmune responseB lymphocytesAutoantigen-presenting cellsProductive immune responseDiverse immune responsesAutoantigen processingAutoimmune diseasesSelf antigensImmune attackSelf constituentsAntigen leadSelf peptidesViral infectionInfectious agentsImmune systemSelf tissuesAntigenPotential roleAutoimmunityLymphocytesEpitopesConcept of epitopeCellsAgentsInfection
1997
B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya
ROTH R, GEE R, MAMULA M. B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya. Annals Of The New York Academy Of Sciences 1997, 815: 88-100. PMID: 9186642, DOI: 10.1111/j.1749-6632.1997.tb52047.x.Peer-Reviewed Original ResearchConceptsB cell-deficient miceCell-deficient miceNaive T cellsT cellsSelf antigensIL-4IL-5B cellsB7-2 costimulatory moleculesAutoantigen-presenting cellsAutoreactive T cellsT cell toleranceAntigen-presenting cellsCytokine mRNA responsesB cell subsetsNaive lymphAutoimmune responseCell subsetsCostimulatory moleculesAntigen presentationCytokine mRNAIFN-gammaB lymphocytesCell toleranceMRNA response
1996
B7 costimulation and autoantigen specificity enable B cells to activate autoreactive T cells.
Roth R, Nakamura T, Mamula M. B7 costimulation and autoantigen specificity enable B cells to activate autoreactive T cells. The Journal Of Immunology 1996, 157: 2924-31. PMID: 8816398, DOI: 10.4049/jimmunol.157.7.2924.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntibodies, MonoclonalAntigen PresentationAntigens, CDAutoantigensAutoimmunityB-LymphocytesB7-1 AntigenB7-2 AntigenBase SequenceCell MovementCytochrome c GroupCytokinesFemaleGene Expression RegulationImmunizationLymph NodesLymphocyte ActivationMembrane GlycoproteinsMiceMolecular Sequence DataPeptide FragmentsPolymerase Chain ReactionRatsRNA, MessengerSelf ToleranceSignal TransductionT-Lymphocyte SubsetsConceptsAutoreactive T cellsT cell responsesT cellsB cellsIL-4IL-5Self-AgImmunized B-cell-deficient miceCell responsesAutoimmune T cell responsesB cell-deficient miceB7-1 costimulatory moleculeT cell autoimmunityCell-deficient miceTreatment of miceT cell toleranceNaive T cellsCytokine mRNA responsesCell autoimmunityB7 costimulationCostimulatory moleculesAutoantigen specificityB7-2Cytokine mRNAIFN-gamma
1994
The expression of self antigenic determinants: implications for tolerance and autoimmunity
Mamula M, Craft J. The expression of self antigenic determinants: implications for tolerance and autoimmunity. Current Opinion In Immunology 1994, 6: 882-886. PMID: 7536009, DOI: 10.1016/0952-7915(94)90008-6.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsT cellsSelf peptidesSelf antigenic determinantsT cell responsesPathogenesis of autoimmunityMajor histocompatibility moleculesNormal lymphocytesAntigen processingAntigenic determinantsHistocompatibility moleculesAutoimmunityCell surface proteinsNormal pathwayCellsPeptidesLymphocytesPathogenesis
1992
Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c.
Mamula M, Lin R, Janeway C, Hardin J. Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c. The Journal Of Immunology 1992, 149: 789-95. PMID: 1321851, DOI: 10.4049/jimmunol.149.3.789.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAutoantigensAutoimmunityB-LymphocytesCross ReactionsCytochrome c GroupGene Rearrangement, beta-Chain T-Cell Antigen ReceptorHumansImmune ToleranceLymphocyte ActivationMiceMice, Inbred StrainsRatsReceptors, Antigen, T-Cell, alpha-betaSequence AlignmentSpecies SpecificityT-LymphocytesConceptsT cell responsesT cell toleranceB cellsCell responsesCell toleranceSelf-AgAutoimmune T cell responsesAutoreactive T cell responsesAutoreactive T cell clonesTCR genesAutoimmune B cellsCellular immune responsesImmune B cellsAutoreactive B cellsT cell clonesT cell epitopesAmino acids 54Autoimmune diseasesT cellsImmune responseCell epitopesForeign pathogensModel autoantigenImmunizationCell clones
1991
Induction of autoreactive B cells allows priming of autoreactive T cells.
Lin R, Mamula M, Hardin J, Janeway C. Induction of autoreactive B cells allows priming of autoreactive T cells. Journal Of Experimental Medicine 1991, 173: 1433-1439. PMID: 1851798, PMCID: PMC2190847, DOI: 10.1084/jem.173.6.1433.Peer-Reviewed Original Research