2008
Sequential autoantigenic determinants of the small nuclear ribonucleoprotein Sm D shared by human lupus autoantibodies and MRL Ipr/lpr antibodies
JAMES J, MAMULA M, HARLEY J. Sequential autoantigenic determinants of the small nuclear ribonucleoprotein Sm D shared by human lupus autoantibodies and MRL Ipr/lpr antibodies. Clinical & Experimental Immunology 2008, 98: 419-426. PMID: 7527740, PMCID: PMC1534503, DOI: 10.1111/j.1365-2249.1994.tb05507.x.Peer-Reviewed Original ResearchConceptsMRL-lpr/lpr miceLpr/lpr miceAutoimmune serologySLE patientsLpr micePatient seraEpitope 5Systemic lupus erythematosus (SLE) patient seraEpstein-Barr nuclear antigen 1Lupus patients' seraNuclear antigen 1Precipitin-positive seraHuman lupus autoantibodiesNormal human serumMajor antigenic regionSm DPositive patientsAutoimmune responseSm autoantigenLupus autoantibodiesNormal controlsPatientsEpitope 4Mouse serumAntigen 1
1991
Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus.
Silverman E, Mamula M, Hardin J, Laxer R. Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus. The Journal Of Rheumatology 1991, 18: 120-4. PMID: 2023181.Peer-Reviewed Original ResearchConceptsNeonatal lupus erythematosusCongenital heart blockAnti-La antibodiesHeart blockImmune responseLupus erythematosusCutaneous neonatal lupus erythematosusAnti-U1RNP antibodiesAnti-Ro antibodiesRo antibodiesAnti-RoLa antibodiesAntibodiesErythematosusAssay techniquesPrevious studiesResponsePatientsInfantsPathogenesisWomen
1990
The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease.
Mamula M, Jemmerson R, Hardin J. The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease. The Journal Of Immunology 1990, 144: 1835-40. PMID: 1689756, DOI: 10.4049/jimmunol.144.5.1835.Peer-Reviewed Original ResearchConceptsC autoantibodiesC antibodyPresence of autoantibodiesConnective tissue diseaseSpecificity of autoantibodiesAntimitochondrial antibodiesAutoantibody responseTissue diseaseAutoimmune diseasesDisease subsetsSm autoantigenPatient seraAutoantibodiesAnimal modelsModel AgAntibodiesDiseaseSpecificityPatientsSLEAutoantigensMicePathologySerumResponse
1987
Implications of anti-Ro/Sjögren's syndrome A antigen autoantibody in normal sera for autoimmunity.
Gaither K, Fox O, Yamagata H, Mamula M, Reichlin M, Harley J. Implications of anti-Ro/Sjögren's syndrome A antigen autoantibody in normal sera for autoimmunity. Journal Of Clinical Investigation 1987, 79: 841-846. PMID: 3546381, PMCID: PMC424215, DOI: 10.1172/jci112892.Peer-Reviewed Original ResearchConceptsRo/SSAAnti-Ro/SSALa/SSBNormal serumAntigen autoantibodiesSjögren's syndromeAnti-Ro/Sjögren's syndromeRo/Sjögren's syndromeHealthy normal donorsSjögren's syndrome autoantibodiesPreexisting immune responseRo/SSA precipitinsTrue autoantibodiesImmune responseNormal donorsAutoantibodiesSyndromeFragments of IgG.Western immunoblotSSA levelsSerumPatientsSensitive assayLow levelsAutoimmunity