2022
Biomarkers of autoimmunity and beta cell metabolism in type 1 diabetes
Yang M, Kibbey R, Mamula M. Biomarkers of autoimmunity and beta cell metabolism in type 1 diabetes. Frontiers In Immunology 2022, 13: 1028130. PMID: 36389721, PMCID: PMC9647083, DOI: 10.3389/fimmu.2022.1028130.Peer-Reviewed Original ResearchConceptsPosttranslational protein modificationMetabolic pathwaysType 1 diabetesCellular metabolic pathwaysImportant biological functionsAutoimmune diseasesBeta cellsCellular metabolic dysfunctionPancreatic isletsProtein modificationBiological functionsProtein structureInsulin-producing beta cellsBiomarkers of autoimmunityChronic autoimmune diseaseCell metabolismBeta-cell metabolismNumerous autoimmune diseasesPancreatic beta cellsPotential pathological consequencesNormal metabolic pathwaysDisease activityPathological consequencesSpecific autoantigensSpecific autoimmunity
2016
Posttranslational modification of islet autoantigens in type 1 diabetes
Yang M, Wen L, Herold K, Mamula M. Posttranslational modification of islet autoantigens in type 1 diabetes. The Journal Of Immunology 2016, 196: 118.9-118.9. DOI: 10.4049/jimmunol.196.supp.118.9.Peer-Reviewed Original ResearchAnti-insulin autoimmunityType 1 diabetesNon-obese diabetic (NOD) micePrediabetic NOD miceDevelopment of T1D.Onset of hyperglycemiaHuman pancreatic isletsNOD miceHuman T1DHuman T1D.Islet autoantigensImmune toleranceAutoimmune responseDiabetic miceAutoimmune diseasesInflammatory cytokinesTissue pathologyPancreatic isletsAutoantibodiesT1D.Islet proteinsAutoantigensOxidative stressInsulin biosynthesisAutoimmunity
2013
Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152)
Yang M, Connolly S, Wen L, Herold K, Mamula M. Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152). The Journal Of Immunology 2013, 190: 172.3-172.3. DOI: 10.4049/jimmunol.190.supp.172.3.Peer-Reviewed Original ResearchNOD miceType 1 diabetesDiabetes-prone NOD miceEarly-onset diabetic patientsPre-diabetic NOD miceDiabetic NOD miceT cell autoimmunityPathogenesis of T1DPancreatic islet proteinsCell autoimmunityDiabetic patientsImmune toleranceRheumatoid arthritisMultiple sclerosisAutoimmune diseasesMurine modelTarget organsTherapeutic targetSelf proteinsPancreatic isletsIslet proteinsMiceOxidative stressPeripheral erythrocytesDiabetes