2013
Therapeutic inhibition of gut antigen trafficking through scavenger receptor A (P5027)
Raycroft M, Mamula M. Therapeutic inhibition of gut antigen trafficking through scavenger receptor A (P5027). The Journal Of Immunology 2013, 190: 110.14-110.14. DOI: 10.4049/jimmunol.190.supp.110.14.Peer-Reviewed Original ResearchScavenger receptor ADendritic cellsAutoantibody productionPeyer's patchesAntigen traffickingReceptor AB cellsLupus-prone miceGut immune responseB cell receptorLupus pathologyAutoimmune diseasesImmune responseTherapeutic inhibitionGut antigensHuman immunitySpecific antigenTherapeutic interventionsMice exhibitCell receptorHuman macrophagesInhibition altersMiceAutoimmunityTLR4
2011
Chapter 8 B-Lymphocyte Biology in SLE
Mamula M. Chapter 8 B-Lymphocyte Biology in SLE. 2011, 143-161. DOI: 10.1016/b978-0-12-374994-9.10008-7.Peer-Reviewed Original ResearchSystemic lupus erythematosusHuman systemic lupus erythematosusAntigen-presenting cellsB cellsDiagnostic hallmarkAutoreactive B cell responsesB-cell-specific therapiesClinical systemic lupus erythematosusB lymphocyte subsetsIgG class autoantibodiesB cell responsesT lymphocyte interactionsMultiple cellular abnormalitiesDendritic cellsLupus erythematosusAutoantibody responseLupus autoantigensClass autoantibodiesT cellsMurine modelB lymphocyte biologyGenetic predispositionReceptor inductionPathologic processesTissue pathology
2008
Scavenger receptor type AI mediates antigen transfer from human B cells to other APCs
Harvey B, Quan T, Roman R, Rudenga B, Craft J, Mamula M. Scavenger receptor type AI mediates antigen transfer from human B cells to other APCs. The FASEB Journal 2008, 22: 1068.14-1068.14. DOI: 10.1096/fasebj.22.1_supplement.1068.14.Peer-Reviewed Original ResearchAntigen-presenting cellsProfessional antigen-presenting cellsB cellsAntigen transferTreatment of lupusInduction of autoimmunityTransfer of antigenUptake of antigensSpecific B cell receptorsNovel therapeutic targetMonocytic cell line THP-1Ig transgenic miceHuman monocytic cell line THP-1Cell line THP-1Human B cellsB cell receptorDendritic cellsChronic autoimmunityArthritis FoundationImmune responseAntigen traffickingB cell deathCritical antigensTherapeutic targetSpecific antigen