2011
Chapter 8 B-Lymphocyte Biology in SLE
Mamula M. Chapter 8 B-Lymphocyte Biology in SLE. 2011, 143-161. DOI: 10.1016/b978-0-12-374994-9.10008-7.Peer-Reviewed Original ResearchSystemic lupus erythematosusHuman systemic lupus erythematosusAntigen-presenting cellsB cellsDiagnostic hallmarkAutoreactive B cell responsesB-cell-specific therapiesClinical systemic lupus erythematosusB lymphocyte subsetsIgG class autoantibodiesB cell responsesT lymphocyte interactionsMultiple cellular abnormalitiesDendritic cellsLupus erythematosusAutoantibody responseLupus autoantigensClass autoantibodiesT cellsMurine modelB lymphocyte biologyGenetic predispositionReceptor inductionPathologic processesTissue pathology
2008
Scavenger receptor type AI mediates antigen transfer from human B cells to other APCs
Harvey B, Quan T, Roman R, Rudenga B, Craft J, Mamula M. Scavenger receptor type AI mediates antigen transfer from human B cells to other APCs. The FASEB Journal 2008, 22: 1068.14-1068.14. DOI: 10.1096/fasebj.22.1_supplement.1068.14.Peer-Reviewed Original ResearchAntigen-presenting cellsProfessional antigen-presenting cellsB cellsAntigen transferTreatment of lupusInduction of autoimmunityTransfer of antigenUptake of antigensSpecific B cell receptorsNovel therapeutic targetMonocytic cell line THP-1Ig transgenic miceHuman monocytic cell line THP-1Cell line THP-1Human B cellsB cell receptorDendritic cellsChronic autoimmunityArthritis FoundationImmune responseAntigen traffickingB cell deathCritical antigensTherapeutic targetSpecific antigen
1997
B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya
ROTH R, GEE R, MAMULA M. B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya. Annals Of The New York Academy Of Sciences 1997, 815: 88-100. PMID: 9186642, DOI: 10.1111/j.1749-6632.1997.tb52047.x.Peer-Reviewed Original ResearchConceptsB cell-deficient miceCell-deficient miceNaive T cellsT cellsSelf antigensIL-4IL-5B cellsB7-2 costimulatory moleculesAutoantigen-presenting cellsAutoreactive T cellsT cell toleranceAntigen-presenting cellsCytokine mRNA responsesB cell subsetsNaive lymphAutoimmune responseCell subsetsCostimulatory moleculesAntigen presentationCytokine mRNAIFN-gammaB lymphocytesCell toleranceMRNA response
1994
The expression of self antigenic determinants: implications for tolerance and autoimmunity
Mamula M, Craft J. The expression of self antigenic determinants: implications for tolerance and autoimmunity. Current Opinion In Immunology 1994, 6: 882-886. PMID: 7536009, DOI: 10.1016/0952-7915(94)90008-6.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsT cellsSelf peptidesSelf antigenic determinantsT cell responsesPathogenesis of autoimmunityMajor histocompatibility moleculesNormal lymphocytesAntigen processingAntigenic determinantsHistocompatibility moleculesAutoimmunityCell surface proteinsNormal pathwayCellsPeptidesLymphocytesPathogenesis