Ebf1-dependent control of the osteoblast and adipocyte lineages
Hesslein DG, Fretz JA, Xi Y, Nelson T, Zhou S, Lorenzo JA, Schatz DG, Horowitz MC. Ebf1-dependent control of the osteoblast and adipocyte lineages. Bone 2008, 44: 537-546. PMID: 19130908, PMCID: PMC2657874, DOI: 10.1016/j.bone.2008.11.021.Peer-Reviewed Original ResearchConceptsNumber of osteoclastsBone formation parametersBone formation rateAdipocyte lineageBone marrow cellsOlfactory sensory neuronsSerum osteocalcinOsteoid volumeSensory neuronsAdipocyte numberBone marrowOsteoclast developmentMutant miceMarrow cellsMiceSubcutaneous sitesBone formationAdipocyte developmentStriking increaseDecreased depositionTranscription factorsOsteoblastsB cell fate specificationEBF1AdiposityThe role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation
Ciovacco WA, Goldberg CG, Taylor AF, Lemieux JM, Horowitz MC, Donahue HJ, Kacena MA. The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation. Bone 2008, 44: 80-86. PMID: 18848655, PMCID: PMC2659565, DOI: 10.1016/j.bone.2008.08.117.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAnimalsAnimals, NewbornCalciumCell CommunicationCell DifferentiationCell LineCell ProliferationConnexin 43Extracellular SpaceFemaleFlow CytometryGap JunctionsGene Expression RegulationGlycyrrhetinic AcidHumansMegakaryocytesMiceOleic AcidsOsteoblastsPregnancyReverse Transcriptase Polymerase Chain ReactionTritiumConceptsGJ intercellular communicationGene expressionIntercellular communicationGap junctionsOB proliferationMembrane-spanning channelsAbility of megakaryocytesPhosphatase enzymatic activityAlkaline phosphatase enzymatic activityOsteoblast proliferationBone cellsGJ proteinsPotential novel targetSignaling mechanismMatrix proteinsNodule formationEnzymatic activityEnzymatic levelsNovel targetMegakaryocytesDifferentiationOB culturesProteinConnexin 43Proliferation