2024
Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction
Plummer J, Horowitz M, Johnson J. Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction. Aging Biology 2024, 2: 20230019. PMID: 38550776, PMCID: PMC10977905, DOI: 10.59368/agingbio.20230019.Peer-Reviewed Original ResearchMetabolic health benefitsBone massMethionine restrictionContinuous MRStatic histomorphometric analysisAccumulation of marrow fatMarrow fat accumulationLean body massMethionine-restricted dietLong-term adherenceCortical boneFemale miceMale miceDietary interventionHistomorphometric analysisDeleterious effectsContinuous interventionMarrow fatMiceAge-related pathologiesIntermittent formMammalian healthspanBoneConsistent with such findingsStrength of bone
2008
Ebf1-dependent control of the osteoblast and adipocyte lineages
Hesslein DG, Fretz JA, Xi Y, Nelson T, Zhou S, Lorenzo JA, Schatz DG, Horowitz MC. Ebf1-dependent control of the osteoblast and adipocyte lineages. Bone 2008, 44: 537-546. PMID: 19130908, PMCID: PMC2657874, DOI: 10.1016/j.bone.2008.11.021.Peer-Reviewed Original ResearchConceptsNumber of osteoclastsBone formation parametersBone formation rateAdipocyte lineageBone marrow cellsOlfactory sensory neuronsSerum osteocalcinOsteoid volumeSensory neuronsAdipocyte numberBone marrowOsteoclast developmentMutant miceMarrow cellsMiceSubcutaneous sitesBone formationAdipocyte developmentStriking increaseDecreased depositionTranscription factorsOsteoblastsB cell fate specificationEBF1Adiposity