Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction
Plummer J, Horowitz M, Johnson J. Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction. Aging Biology 2024, 2: 20230019. PMID: 38550776, PMCID: PMC10977905, DOI: 10.59368/agingbio.20230019.Peer-Reviewed Original ResearchMetabolic health benefitsBone massMethionine restrictionContinuous MRStatic histomorphometric analysisAccumulation of marrow fatMarrow fat accumulationLean body massMethionine-restricted dietLong-term adherenceCortical boneFemale miceMale miceDietary interventionHistomorphometric analysisDeleterious effectsContinuous interventionMarrow fatMiceAge-related pathologiesIntermittent formMammalian healthspanBoneConsistent with such findingsStrength of bone