Fast, sensitive detection of protein homologs using deep dense retrieval
Hong L, Hu Z, Sun S, Tang X, Wang J, Tan Q, Zheng L, Wang S, Xu S, King I, Gerstein M, Li Y. Fast, sensitive detection of protein homologs using deep dense retrieval. Nature Biotechnology 2024, 1-13. PMID: 39123049, DOI: 10.1038/s41587-024-02353-6.Peer-Reviewed Original ResearchProtein language modelsRemote homologsProtein homologsProtein sequence comparisonsAlignment-based approachesWell-characterized proteinsPSI-BLASTSuperfamily levelProtein evolutionSequence comparisonProtein sequencesHomologyProteinSensitivity compared to previous methodsSensitive detectionHMMERSuperfamilyStructural informationSequence