2013
Notch signalling beyond liver development: Emerging concepts in liver repair and oncogenesis
Morell CM, Fiorotto R, Fabris L, Strazzabosco M. Notch signalling beyond liver development: Emerging concepts in liver repair and oncogenesis. Clinics And Research In Hepatology And Gastroenterology 2013, 37: 447-454. PMID: 23806629, DOI: 10.1016/j.clinre.2013.05.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsBile Duct NeoplasmsBiliary TractCalcium-Binding ProteinsCarcinogenesisCarcinoma, HepatocellularCholangiocarcinomaHepatocytesHumansIntercellular Signaling Peptides and ProteinsJagged-1 ProteinLiverLiver NeoplasmsLiver RegenerationMembrane ProteinsReceptor Cross-TalkReceptors, NotchSerrate-Jagged ProteinsSignal TransductionNotch signaling regulates tubular morphogenesis during repair from biliary damage in mice
Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M. Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. Journal Of Hepatology 2013, 59: 124-130. PMID: 23500150, PMCID: PMC3777645, DOI: 10.1016/j.jhep.2013.02.025.Peer-Reviewed Original ResearchMeSH Keywords1-NaphthylisothiocyanateAmyloid Precursor Protein SecretasesAnimalsBile Ducts, IntrahepaticCalcium-Binding ProteinsImmunoglobulin J Recombination Signal Sequence-Binding ProteinIntercellular Signaling Peptides and ProteinsJagged-1 ProteinLiver RegenerationMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMorphogenesisPyridinesReceptor, Notch2RNA, Small InterferingSerrate-Jagged ProteinsSignal TransductionStem CellsConceptsWild-type miceHepatic progenitor cellsBiliary damageType miceProgenitor cellsDuctular reactionΓ-secretase inhibitor treatmentTubule formationNotch signalingNotch-2 receptorRBP-JkBiliary repairMature ductsLiver-specific defectCKO miceInhibitor treatmentAbstractTextMiceNotch inhibitionNotch-1Jagged-1Notch-2ANITAIMSSOX-9
2000
Advances in familial and congenital cholestatic diseases. Clinical and diagnostic implications
Colombo C, Okolicsanyi L, Strazzabosco M. Advances in familial and congenital cholestatic diseases. Clinical and diagnostic implications. Digestive And Liver Disease 2000, 32: 152-159. PMID: 10975791, DOI: 10.1016/s1590-8658(00)80403-x.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesATP Binding Cassette Transporter, Subfamily BATP-Binding Cassette TransportersCalcium-Binding ProteinsCholestasisDiagnosis, DifferentialGenetic MarkersGenetic Predisposition to DiseaseHumansIntercellular Signaling Peptides and ProteinsJagged-1 ProteinMembrane ProteinsMolecular BiologyMutationPhenotypeProteinsSerrate-Jagged ProteinsConceptsGenetic analysisP-type ATPasesUnknown physiological functionBile salt export pump geneDifferent genetic diseasesProgressive familial intrahepatic cholestasis patientsAnalysis of mutationsCell fateEarly embryogenesisLiver cell biologyCell biologyMolecular geneticsPhysiological functionsGenesGenetic diseasesCanalicular bile salt export pumpSpecific mutationsMDR3 proteinMutationsJagged-1Export pumpNotch-1Acid synthesisAcid analysisBile salt export pump