2011
Epithelial–Mesenchymal Interactions in Biliary Diseases
Fabris L, Strazzabosco M. Epithelial–Mesenchymal Interactions in Biliary Diseases. Seminars In Liver Disease 2011, 31: 011-032. PMID: 21344348, PMCID: PMC3729030, DOI: 10.1055/s-0031-1272832.Peer-Reviewed Original ResearchConceptsReactive cholangiocytesChemo/cytokinesBile secretory functionLiver repair mechanismsDe novo expressionDifferent mesenchymal cell typesMost cholangiopathiesCell typesPortal fibrosisPortal infiltratesLiver diseaseBiliary diseaseUnderlying molecular mechanismsBiliary epitheliumDifferent etiologiesLiver repairSecretory functionNovo expressionCholangiopathyBiliary cellsCentral mechanismsMesenchymal cell typesMesenchymal propertiesEndothelial cellsGrowth factor
2008
Functional Anatomy of Normal Bile Ducts
Strazzabosco M, Fabris L. Functional Anatomy of Normal Bile Ducts. The Anatomical Record 2008, 291: 653-660. PMID: 18484611, PMCID: PMC3743051, DOI: 10.1002/ar.20664.Peer-Reviewed Original ResearchConceptsBile ductBiliary treeExtrahepatic bile ductSmall bile ductsNormal bile ductsLiver progenitor cellsBile productionBiliary epitheliumMajor ductsSecretory functionVascular structuresProgenitor cellsCholangiocyte functionFunctional anatomyBileDuctCholangiocytesIntestineFunctional interactionMorphological heterogeneityNerveGallbladderVariety of functionsEpithelium
1997
Transport systems in cholangiocytes: their role in bile formation and cholestasis.
Strazzabosco M. Transport systems in cholangiocytes: their role in bile formation and cholestasis. The Yale Journal Of Biology And Medicine 1997, 70: 427-34. PMID: 9626763, PMCID: PMC2589334.Peer-Reviewed Original ResearchConceptsBiliary epitheliumCa-activated Cl channelsChronic cholestatic disorderPathogenesis of cholestasisBile duct diseaseCholangiocyte deathFormation of bilePortal inflammationBiliary cirrhosisProinflammatory mediatorsLiver diseaseClinical picturePathophysiological pointCholestatic disordersDuct diseaseProliferative responseBiliary constituentsBile acidsCystic fibrosisPortal spacesSecretory functionBile formationCholestasisDuctular secretionSecretory activity